EFFECT OF VITAMIN C AND ZINC ON SOME BIOCHEMICAL PARAMETER IN ALLOXAN INDUCED DIABETIC RABBITS
2013
Zainab A. H. Al-Mousawi
Diabetes mellitus (DM) a disease which is characterized by hyperglycemia, lipoprotein abnormalities and oxidative stress. This study was undertaken to investigate the beneficial effect of vitamin C and Zinc on some biochemical parameter when induced diabetic in rabbits by alloxan. Male rabbits groups divided into four groups: Group I (Negative control) received normal saline orally, alloxan diabetic rabbits : Group II (Positive control) received normal saline orally , while Group III were orally administered 50 mg/kg body weight of vitamin C and group IV were orally administered 100 mg/kg body weight Zinc for 15 days. The results showed that vitamin C administration and zinc significantly (P< 0.05) reduced the serum glucose, total cholesterol, triglyceride, ALT and AST concentration, while there were significant changes (p< 0.05) was observed on the serum levels of total protein, albumin, globulin and albumin/ globulin ratio in diabetic group treated with vitamin C, Zinc respectively.
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