TOXICOLOGICAL PATHOLOGY OF NAPROXEN (NSAIDS) ON GASTRO-INTESTINAL TRACT IN WHITE RATS
2014
Thaer Ali | Zainab W. Khudair | Saleh K. Majeed
The current study was accomplished to investigate the toxicity of naproxen sodium (NAP) in white rats, and then to detect the pathogenesis of NSAIDs-induced gastro-intestinal injury. The study included the usage of main effective(naproxen) on (48) male and female white rats, They were divided into four groups, and each group contained(12) rats, divided as follows. group-C, which treated with normal saline, group(L) was low dose which received (5mg/kg) of naproxen sodium, group(I) was given intermediate dose ,which received (10mg/kg) and group(H) represented high dose, which received (20mg/kg). The drug administrated by oral gavage for three months. Results of the study included the macroscopic changes such as minimal changes of the gastric mucosa or lining epithelium in the wall of stomach, also included ulceration of the small intestine, in addition there was increase length of the villi and presence of inflammatory cells in lamina properia, and also there was degeneration of mucosal epithelium and mucosal glands in the lamina propria of the stomach, There was vacuolation of mucous lining cells of the stomach, and there was inflammatory cells in the serosa, presence of prominant ganglionic cells in the distal part of muscularis externa of the stomach. The pathological changes of high dose of naproxen was more severe than intermediate dose(group-I) and low dose(group- L).
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