ACUTE TOXICITY STUDY OF NEW DAPSONE SCHIFF BASE DERIVATIVE IN LABORATORY RATS

Wasfi A. Al-masoudi; Hassan T. hamed; Jalaa Al- ahamed

ACUTE TOXICITY STUDY OF NEW DAPSONE SCHIFF BASE DERIVATIVE IN LABORATORY RATS

2014

Wasfi A. Al-masoudi | Hassan T. hamed | Jalaa Al- ahamed

Dapsone (4,4-diaminodiphenylsulphon) is one of the types of sulfa drugs as an anti bacterial and is used particularly in the treatment of leprosy . The aim of present study to investigate in vivo toxic effect and find acute toxic doses ( LD50) of new dapsone Schiff base derivative compound ( 4-{[ 4(ethylideneamino)phenyl] sulfonyl} aniline, was evaluated in this study. The experiment was performed on 10-14-week old male and female albino rats ( 225± 25 g ) at the time of treatment. Its acute toxic dose being 0.58 g.

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