IN VIVO ACTIVITY OF GREEN ZINC OXIDE NANOPARTICLES AGAINST Leishmania donovani USING ALBINO MALE RATS
2018
Ahmed Hamad Saleh
The present study was designed to show the potential role of zinc oxide nanoparticles againstthe toxicity of L. donovani. The study were conducted on 15 adult male rats that arranged inthree groups (5 rates for each), The control group that received normal saline, The second is thegroup with rats injected with L. donovani at dose rate of 1.2× 1 0 6 cell/ 0.2ml . intraperitoneally,The third group is rats injected with L. donovani at a dose rate of 1.2× 1 0 6 cell/ 0.2ml andtreated with50ug/kg of ZnO-NPs for two weeks. The results show a high significant increased (P< 0.05) in levels of Malondialdehyde (MDA) and a high significant decreased (P < 0.05) inlevels of GSH, catalase in the second group compared with the controls. The results of thirdgroup showed non-significant changes (P < 0.05) in all parameters compared with controls whenusing green zinc oxide nanoparticles. The results of the histopathological study of sectionsprepared from animals of the second group indicated a thickening wall of bronchiole in mostregions with sever lymphocytes infiltration and damage in wall of alveoli. However , Aftertreatment, the sections that prepared from the third group show a semi-normal structure ofbronchiole, alveolar sac and alveoli. It has been was concluded that green zinc oxidenanoparticles have the true been potential role against the toxicity of L. donovani in adult malerats.
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