SYNTHESIS AND PHYSIOLOGICAL STUDY OF SCHIFF BASE DERIVED FROM SULFANILAMIDE AND VANILINE
2020
Hanadi Abadul Gabar Al-Halfi | Wasfi Aboud Al-Masoudi | Ahlam Ali Alrekabi
The design and production of innovative and safer drugs attracted to organicchemists is urgently required in order to synthesize new compounds with the potentialof biological and chemotherapeutic activities. We're reporting here, the condensationof 4-aminobenzene-1-sulfonamide (sulphanilamide drug) with 4-Hydroxy-3-methoxybenzaldehyde(vanillin), yielded derivative of Schiff base in good yield. Elementalanalysis (CHN), IR, 1H and 13C-NMR spectroscopy were used to characterize thesynthesized compound. Using the Balb/c mouse model, the toxicity of thesynthesized compound was determined. The up and down method of Dixon wasfound to have a body weight of 1677.2 mg / kg LD50 and mild toxicity. The resultsshowed the ability of the prepared compound to improve the TWBC and DWBCvalues approach to control, giving HSV a less harmful effect than the sulfanilamidedrug.
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