TNF-a and FGF immunohistochemical expressions and pathological evaluation of the duck's liver lesions in Mosul city
2025
Soadd M. Alhamdani | Ahmed N. Flayyih | Ayman A. Al-Alhially
This research focuses on studying liver illnesses in ducks in Mosul city by analyzing the expression of TNF alpha and FGF proteins as indicators of inflammation and abnormal growths in the liver tissues samples were collected from duck liver in Mosul city from November 2022 to November 2023 to detect any pathological changes and occurrences infections. Histopathological observations unveiled abnormalities such as inflammation and extensive tissue damage noted as foci of coagulative necrosis of the hepatocytes, focal infiltration of inflammatory cells, and severe fatty degeneration of the hepatocytes. The results also demonstrated severe massive hydropic degeneration of the hepatocytes, proliferation of Kupffer cells, and expansion of sinusoids. Immunohistochemical tests revealed TNF alpha expression in inflamed regions with a presence in the injured areas, suggesting a robust inflammatory reaction is underway. Conversely, FGF was detected in the regions that demonstrated regrowth, highlighting its vital role in fibrous tissue restoration. The histopathological changes among ducks soared to 52%, indicating an occurrence of liver disorders within the duck population. This research offers information about liver lesions in ducks in Mosul City and helps enhance our understanding of the causes and signs of diseases affecting them. The immunohistochemical results concerning TNF alpha and FGF provide insights into disease progression processes, potentially setting the stage for better treatment and prevention strategies.
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