Impactul nutriției asupra bolii coronariene

Zaharia, Mihaela; Surdu, Adelina

Impactul nutriției asupra bolii coronariene

2024

Zaharia, Mihaela | Surdu, Adelina

Coronary coronary artery disease (CAD) is the leading cause of morbidity and mortality worldwide and has been characterized as a chronic immunoinflammatory, lipid-fueled fibroproliferative lipid-mediated chronic inflammatory disease. Much progress has been made in elucidating the complex mechanistic interactions among the risk factors associated with BC, yielding abundant success in preventive measures and the development of pharmaceuticals to prevent and treat BC by mitigating lipoprotein-mediated risk. However, a significant residual risk remains. Several potentially modifiable BC risk factors that apparently contribute to this residual risk have come to the forefront, including systemic inflammation, diabetes mellitus, high-density lipoproteins, plasma triglycerides (TG) and remnant lipoproteins (RLP), lipoprotein(a) and vascular endothelial dysfunction (ED). The first step in managing BC risk factors involves manipulation of macronutrients in the diet. In the Lipid Research Clinics Coronary Primary Prevention Trial, it was determined that each 1% decrease in LDL cholesterol (LDL-C) was associated with a 2% decrease in the risk of BC. These findings formed the basis of the National Cholesterol Education Program (NCEP) recommended for both men and women with hypercholesterolemia.

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