Balancing Efficacy and Safety: A Comprehensive Review of Fentanyl, Medetomidine, and Their Antagonists in Human and Veterinary Medicine
2025
Diana Bianca ZALISCHI | Laura CATANA | Mihai Sorin CERNEA
This review comprehensively examines the use of sedative and analgesic medications, focusing on opioids and α2 adrenergic agonists in both veterinary and human medicine. These pharmacological agents are crucial for pain management, sedation, and anesthesia protocols across different species. The review explores the pharmacokinetics, pharmacodynamics, mechanisms of action, therapeutic applications, and the risks associated with their use, such as potential for overdose, dependency, and adverse effects. Emphasis is placed on commonly used substances like fentanyl and medetomidine, their molecular interactions, and the differences in receptor sensitivity and response across species.
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