The antimicrobial peptides derived from chromogranin/secretogranin family, new actors of innate immunity
2009
Shooshtarizadeh, Peiman | Zhang, Dan | Chich, Jean-François | Gasnier, Claire | Schneider, Francis | Haïkel, Youssef | Aunis, Dominique | Metz-Boutigue, Marie-Hélène | Physiopathologie du système nerveux. ; Université Louis Pasteur - Strasbourg I-IFR37-Institut National de la Santé et de la Recherche Médicale (INSERM) | Unité de recherche Virologie et Immunologie Moléculaires (VIM (UR 0892)) ; Institut National de la Recherche Agronomique (INRA) | Hôpital de Hautepierre [Strasbourg] ; Hôpitaux Universitaires de Strasbourg (HUS) | Université de Strasbourg (UNISTRA) | BRAHMS | Faculté de Chirurgie Dentaire de Strasbourg | Délégation à la Recherche Clinique des Hôpitaux Universitaires de Strasbourg | Fondation Transplantation
International audience
显示更多 [+] 显示较少 [-]英语. Chromogranins/secretogranins are members of the granin family present in secretory vesicles of nervous, endocrine and immune cells. In chromaffin cells, activation of nicotinic cholinergic receptors induces the release, with catecholamines, of bioactive peptides resulting from a natural processing. During the past decade, our laboratory has characterized new antimicrobial chromogranin-derived peptides in the secretions of stimulated bovine chromaffin cells. They act at the micromolar range against bacteria, fungi, yeasts, and are non-toxic for the mammalian cells. They are recovered in several biological fluids involved in defence mechanisms (human serum, neutrophil secretions and saliva). These new antimicrobial peptides demonstrate the major role of the adrenal medulla in innate immunity. In this review we focus on the antimicrobial peptides derived from human and bovine chromogranin A (CGA), chromogranin B (CGB) and secretogranin II (SGII) emphasizing their direct action against pathogens and their effects on immune cells.
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