Molecular determinism of specific anosmia to 2-bromo-4-methylphenol
2017
Tempere, Sophie | Schaaper, Marie-Hélène | Lytra, Georgia | Barbe, Jean-Christophe | Riquier, Laurent | Marion, Stéphanie | de Revel, Gilles | Sicard, Gilles | Unité de Recherche Oenologie [Villenave d'Ornon] (OENO) ; Institut National de la Recherche Agronomique (INRA)-Université de Bordeaux (UB)-Institut des Sciences de la Vigne et du Vin (ISVV) | Neurobiologie des interactions cellulaires et neurophysiopathologie - NICN (NICN) ; Institut National de la Recherche Agronomique (INRA)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
Several studies have revealed considerable variations in human chemosensory capacities. Considerable interindividual differences in sensitivity to various odorants and specific hyposmias are well known. Many chemical studies have focused on elucidating structure-odour relationships on the basis of detection threshold measurements. The basic idea of quantitative structure-activity relationship studies is that a molecule's structure provides information about its biological activity. In a recent sensory assay of 2-bromo-4-methylphenol, Barbe et al. (2014) highlighted a noticeable bimodal distribution of individual sensitivity with large interindividual differences. The aim of the present study was to investigate the link between the chemical structure of 2-bromo-4-methylphenol and this bimodal distribution. The olfactory phenotypes for a selection of six structurally related halogenated compounds were compared using detection thresholds determination. This study revealed that specific anosmia for 2-bromo-4-methylphenol was apparently linked to the halogenated substitution position.
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