A NOVEL THERAPEUTIC COMBINATION OF VINCRISTINE AND IVERMECTIN IN THE TREATMENT OF TRANSMISSIBLE VENEREAL TUMOUR IN BITCHES
2022
R. Sree Hari Reddy | M. Srinivas | K. Sunny Praveen
The transmissible venereal tumour (TVT) is a contagious neoplasm that is sexually transmitted between dogs. TVT lesions affect the mucus membranes of the external genitalia in dogs of both sexes. Tumour masses are seen in the caudal aspect of the penis and frequently the prepuce area in males and the posterior vaginal area, particularly the vestibule vaginal junction of females. Sixteen bitches of various ages (2-6 years) and breeds were brought to the clinics at Veterinary Clinical Complex, Gannavaram with the history of continuous oozing of blood from vagina, anorexia and depression. All these were diagnosed as TVT based on the history, clinical symptoms and cytological examination and therapy was initiated. At weekly intervals, all the bitches were administered with combination therapy of Vincristine sulphate (0.025 mg/kg body weight, strict and slow I/V) and Ivermectin (0.2 mg/kg body weight, strict S/C) for four consecutive weeks. All of the bitches underwent significant reduction in tumour size with improvement in general health during the course of therapy with exception that one bitch showed signs of anorexia and dullness.
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