ALLEVIATIVE EFFECT OF AQUEOUS EXTRACT OF ASPARAGUS RACEMOSUS ON THE HAEMATO-BIOCHEMICAL PARAMETERS OF EXPERIMENTALLY INDUCED POLYCYSTIC OVARIAN SYNDROME IN WISTAR RATS
2025
C. Vishnuvardhan | N. Pazhanivel | Ganne Venkata Sudhakhar Rao | M. Parthiban
Polycystic ovarian syndrome (PCOS) is a combination of endocrine and metabolic syndrome contributing to both the terms as a clinical feature in women. The present study was conducted to find the alleviative effect of aqueous extract of Asparagus racemosus against the induced PCOS in Wistar rats. About 60 Wistar rats (n=10) are randomly divided into 6 groups: Group 1 (control group), Group 2 (Asparagus racemosus control), Group 3 (PCOS control estradiol valerate 5 mg/rat), Group 4 (estradiol valerate + 1000 mg/kg Asparagus racemosus Prophylactic treatment from day 1 of induction of PCOS), Group 5 (estradiol valerate + 100 mg/kg Asparagus racemosus treatment, after induction of PCOS), Group 6 (Metformin 100 mg/kg). Haematological parameters such as glucose, total protein, albumin, ALT, AST, ALP, triglycerides, cholesterol, C reactive proteins, BUN and creatinine were studied in polycystic ovarian syndrome. Metformin group showed highly significant (P<0.01) reduction in haemoglobin, Packed Cell Volume (PCV) and significant (P< 0.05) reduction in Total Erythrocyte Count (TEC) compared to prophylactic, therapeutic and PCOS groups while PCOS group showed elevation in platelet count (P< 0.05). Significant increase (p < 0.05) in serum glucose, cholesterol and CRP noticed in the PCOS groups compared to prophylactic, therapeutic and metformin groups. The results indicated that Asparagus racemosus had partial alleviating effect on haemato-biochemical parameters caused by polycystic ovarian syndrome in Wistar rats.
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