Galectin-12 in the Regulation of Sebocyte Proliferation, Lipid Metabolism, and Immune Responses
2025
Ching-Han Tsao | Wei-Chen Hsieh | Feng-Jen Lin | Fu-Tong Liu | Ri-Yao Yang
Galectin-12, a member of the galectin family of glycan-binding proteins, exhibits restricted tissue distribution, primarily in adipocytes and sebocytes. In sebocytes, it modulates the cell cycle, influences lipid metabolism through interactions with peroxisome proliferator-activated receptor γ (PPARγ), and exerts immunomodulatory functions by activating immune signaling pathways. Dysregulation of sebocyte homeostasis, lipid metabolism, and immune responses contributes to the pathogenesis of a number of skin diseases, underscoring the therapeutic potential of targeting galectin-12. The review summarizes and discusses current developments in the field to foster future research in this important but underexplored galectin.
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