The effect of colloidal silver on clinical, morphological parameters and mineral composition of blood of calves

The problem of the calf livestock to be preserved under the use restriction conditions of the antibiotics in case of the infectious diseases requires the search for alternative antimicrobial agents, to which the nanocompounds of the noble metals are belonged. The influence of the colloid silver solution on the indicators of the clinical condition, mineral turnover and morphological composition of the blood of the black-pied Holstein calves aged from birth to 30 days had been analyzed. It had been established that the calf rearing with the colloid silver solution composed of colostrum (milk) at a dose of 1.0 and 2.0 mg/l from the 1-st to the 10-th day every twenty-four hours, from the 11-th to the 30-th day, which is carried out once a decade, does not influence on the indicators of the clinical condition, but dose-dependently contributes to the increasing silver content in the blood. Nanosilver at a dose of 2.0 mg/l of colostrum causes the increasing iron and zinc accumulation in the blood of the calves on the 3-rd day after birth. With the increasing calf age up to 30 days as well as with the increasing oral use interval of the colloid silver solution, its influence on the exchange of zinc, iron and copper in the blood is decreased. On the 3-rd and 10-th day after the calf rearing with the colloid silver solution at a dose of 1.0 mg/l, the erythrocyte number reduction in their blood was found by 15.0 % and 12.3 %, the dose of nanosilver of 2.0 mg/l of colostrum causes a similar influence only on the 10-th day. On the 30-th day after the increasing interval of the calf rearing the erythrocyte number in the blood of both studied groups had been equal with the control one. The leukocyte number in the blood of the healthy calves practically did not depend on the dose of the colloid silver, as well as on its use period. The dose of the colloid silver equal to 2.0 mg/l of colostrum (milk) influences on the blood leukogram in a lesser extent than the dose equal to 2.0 mg/l, but both drug doses for 30-th day increase the lymphocyte percentage in the blood of the healthy calves. The obtained results make it possible to select an effective dose and interval of nanosilver application to the calves, taking into account the indicators of their clinical condition, mineral turnover and morphological composition of the blood, as well as to consider it as a prophylactic agent in case of the infectious diseases