A Facile Synthesis of Functionalized Dispirooxindole Derivatives via a Three-Component 1,3-Dipolar Cycloaddition Reaction
2013
Jun He | Guang Ouyang | Zhixiang Yuan | Rongsheng Tong | Jianyou Shi | Liang Ouyang
An efficient synthesis of novel dispirooxindoles has been achieved through three-component 1,3-dipolar cycloaddition of azomethine ylides generated in situ by the decarboxylative condensation of isatin and an α-amino acid with the dipolarophile 5-benzylideneimidazolidine-2,4-dione. The improved procedure features mild reaction conditions, high yields, high diastereoselectivities, a one-pot procedure and operational simplicity.
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Molecules
卷
18
期
5
ISSN
1420-3049
出版者
Multidisciplinary Digital Publishing Institute
页码
p.5142-5154
其它主题
Azomethine ylide; 3-dipolar cycloaddition; Multicomponent reactions; Dispirooxindole
语言
英语
类型
Journal Article
2025-07-18
AGRIS AP
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