Modification of Marine Natural Product Ningalin B and SAR Study Lead to Potent P-Glycoprotein Inhibitors
2014
Chao Yang | Iris Wong | Wen Jin | Tao Jiang | Larry Chow | Sheng Wan
In this study, new marine ningalin B analogues containing a piperazine or a benzoloxy group at ring C have been synthesized and evaluated on their P-gp modulating activity in human breast cancer and leukemia cell lines. Their structure-activity relationship was preliminarily studied. Compounds 19 and 20 are potent P-gp inhibitors. These two synthetic analogues of permethyl ningalin B may be potentially used as effective modulators of P-gp-mediated drug resistance in cancer cells.
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出版者
Multidisciplinary Digital Publishing Institute
页码
p.5209-5221
其它主题
P-glycoprotein; Multidrug resistance (mdr); Ningalin b analogues; P-gp modulators; Pyrrole
语言
英语
类型
Journal Article
2025-07-18
2025-12-04
AGRIS AP
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