Design, Synthesis and Biological Evaluation of Novel Substituted N,N′-Diaryl ureas as Potent p38 Inhibitors
2015
Dianxi Zhu | Xingzhou Li | Wu Zhong | Dongmei Zhao
A novel series of substituted N,N′-diaryl ureas that act as p38α inhibitors have been designed and synthesized based on two key residues (Gly110 and Thr106) that are different in p38α MAPK than in other kinases. Preliminary biological evaluation indicated that most compounds possessed good p38α inhibitory potencies. Among these compounds, 9g appeared to be the most powerful and is the main compound that we will study in the future.
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出版者
Multidisciplinary Digital Publishing Institute
页码
p.16604-16619
其它主题
Tnf-α; Kinase inhibitor; Glycine flip; P38 inhibitors; P38 mapk
语言
英语
类型
Journal Article
2025-07-18
2025-10-23
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