Preventive Potential of Dipeptide Enterocin A/P on Rabbit Health and Its Effect on Growth, Microbiota, and Immune Response
2022
Monika Pogány Simonová | Ľubica Chrastinová | Jana Ščerbová | Valentína Focková | Iveta Plachá | Zuzana Formelová | Mária Chrenková | Andrea Lauková
The present study investigated the effect of the dipeptide enterocin (Ent) A/P on growth, immune response, and intestinal microbiota in rabbits. Eighty-eight rabbits (aged five weeks, M91 meat line, both sexes) were divided into three experimental groups: E (Ent A/P: 50 µ:L/animal/day for 14 days: between 0&ndash:14 days): S (methicillin-resistant Staphylococcus epidermidis SE P3/Tr2a strain: 500 µ:L/animal/day for 7 days starting at day 14 to day 21): and E + S (Ent A/P between 0&ndash:14 days and SE P3/Tr2a strain between 14&ndash:21 days) groups, and the control group (C). The additives were administered in drinking water. Administration of Ent A/P lead to an increase in weight gain, reduction of feed conversion: phagocytic activity was stimulated and gut microbiota were optimized due to reduction of coliforms, total bacterial count, and methicillin-resistant staphylococci. Good health and increased weight gain also showed that methicillin-resistant S. epidermidis SE P3/Tr2a strain did not have any pathogenic effect on rabbits&rsquo: health status.
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