Synthesis, In Silico, and In Vitro Biological Evaluation of New Furan Hybrid Molecules
2022
Stanimir Manolov | Iliyan Ivanov | Dimitar Bojilov | Paraskev Nedialkov
Herein, we report the synthesis of new hybrid molecules between furan and N-containing heterocyclic compounds such as pyrrolidine, 1,2,3,4-tetrahydroquinoline, 1,2,3,4-tetrahydroisoquinoline, and piperidine. The obtained compounds were fully characterized using 1H- and 13C-NMR, UV-Vis, and HRMS spectra. All compounds were assessed for their anti-inflammatory, anti-arthritic, antioxidant, reducing power ability, and chelating activity. The less lipophilic molecules H2 (60.1 ±: 8.16) and H4 (62.23 ±: 0.83) had almost 12 times higher ATA compared with the used ketoprofen (720.57 ±: 19.78) standard. The inhibition of albumin denaturation results makes the newly obtained hybrids potential anti-inflammatory drugs, as the expressed values are higher than the ketoprofen standard (126.58 ±: 5.00), except H3 (150.99 ±: 1.16). All four compounds show significant activity regarding the in vitro biological activities, which makes them great candidates for potential future drugs.
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