Synthesis of meta-Aminophenol Derivatives via Cu-Catalyzed [1,3]-Rearrangement—Oxa-Michael Addition Cascade Reactions
2023
Itaru Nakamura | Mai Tachibana | Riku Konta | Hiroki Tashiro | Masahiro Terada
Cu-catalyzed reactions of N-alkoxy-2-methylanilines and alcohols in the presence of catalytic amounts of IPrCuBr and AgSbF6 afforded the corresponding meta-aminophenol derivatives in good to high yields. These reactions proceed via a [1,3]-rearrangement, in which the alkoxy group migrates from the nitrogen atom to the methyl-substituted ortho position, followed by an oxa-Michael reaction of the resulting ortho-quinol imine intermediate.
显示更多 [+] 显示较少 [-]书目信息
Molecules
卷
28
期
10
ISSN
1420-3049
出版者
Multidisciplinary Digital Publishing Institute
其它主题
Rearrangement; Cascade reaction; Anilines; Copper catalysts
语言
英语
类型
Journal Article
2025-07-18
AGRIS AP
在Google Scholar上查找
如果您发现与此记录相关的任何错误信息，请联系 [email protected]