An Oxidant-Free and Mild Strategy for Quinazolin-4(3H)-One Synthesis via CuAAC/Ring Cleavage Reaction
2023
Yueling He | Zhongtao Yang | Danyang Luo | Xiai Luo | Xiaodong Chen | Weiguang Yang
An oxidant-free and highly efficient synthesis of phenolic quinazolin-4(3H)-ones was achieved by simply stirring a mixture of 2-aminobenzamides, sulfonyl azides, and terminal alkynes. The intermediate N-sulfonylketenimine underwent two nucleophilic additions and the sulfonyl group eliminated through the power of aromatization. The natural product 2-(4-hydroxybenzyl)quinazolin-4(3H)-one can be synthesized on a large scale under mild conditions with this method.
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Molecules
卷
28
期
15
ISSN
1420-3049
出版者
Multidisciplinary Digital Publishing Institute
其它主题
Nucleophilic addition; Ketenimine; Natural product; Quinazolin-4(3h)-ones; Cuaac/ring cleavage reaction
语言
英语
类型
Journal Article
2025-07-18
AGRIS AP
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