Brain Perception of Different Oils on Appetite Regulation: An Anorectic Gene Expression Pattern in the Hypothalamus Dependent on the Vagus Nerve
2024
Gele de Carvalho Araújo Lopes | Brenda Caroline Rodrigues Miranda | João Orlando Piauilino Ferreira Lima | Jorddam Almondes Martins | Athanara Alves de Sousa | Taline Alves Nobre | Juliana Soares Severo | Tiago Eugênio Oliveira da Silva | Milessa da Silva Afonso | Joana Darc Carola Correia Lima | Emidio Marques de Matos Neto | Lucillia Rabelo de Oliveira Torres | Dennys Esper Cintra | Ana Maria Lottenberg | Marília Seelaender | Moisés Tolentino Bento da Silva | Francisco Leonardo Torres-Leal
(1) Background: We examined the effect of the acute administration of olive oil (EVOO), linseed oil (GLO), soybean oil (SO), and palm oil (PO) on gastric motility and appetite in rats. (2) Methods: We assessed food intake, gastric retention (GR), and gene expression in all groups. (3) Results: Both EVOO and GLO were found to enhance the rate of stomach retention, leading to a decrease in hunger. On the other hand, the reduction in food intake caused by SO was accompanied by delayed effects on stomach retention. PO caused an alteration in the mRNA expression of NPY, POMC, and CART. Although PO increased stomach retention after 180 min, it did not affect food intake. It was subsequently verified that the absence of an autonomic reaction did not nullify the influence of EVOO in reducing food consumption. Moreover, in the absence of parasympathetic responses, animals that received PO exhibited a significant decrease in food consumption, probably mediated by lower NPY expression. (4) Conclusions: This study discovered that different oils induce various effects on parameters related to food consumption. Specifically, EVOO reduces food consumption primarily through its impact on the gastrointestinal tract, making it a recommended adjunct for weight loss. Conversely, the intake of PO limits food consumption in the absence of an autonomic reaction, but it is not advised due to its contribution to the development of cardiometabolic disorders.
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