Induction of Different Sensitization Patterns of MRSA to Antibiotics Using Electroporation
2018
Vitalij Novickij | Jurgita Švedienė | Algimantas Paškevičius | Svetlana Markovskaja | Eglė Lastauskienė | Auksė Zinkevičienė | Irutė Girkontaitė | Jurij Novickij
Treatment of bacteria-associated infections is complicated and antibiotic treatment alone is often inadequate to overcome biofilm infections. Physical methods allow overcoming this problem and propose solutions that are non-dependent on drug resistance. In this work, we investigated the feasibility of pulsed electric fields for sensitization of MRSA to common antibiotics. We analyzed the efficacy of inactivation of methicillin-resistant Staphylococcus aureus in 5&ndash:20 kV/cm electric field separately and in combination with gentamicin, doxycycline, ciprofloxacin, sulfamethoxazole, and vancomycin. Combined treatment allowed using up to 1000-fold smaller concentrations of antibiotics to induce the same inactivation of S. aureus.
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