An Increase of Adropin Can Predict Depression Improvement
2025
Duška Krnić | Sara Sablić | Maja Marinović Guić | Danijela Budimir Mršić | Dragan Krnić | Romilda Roje | Daniela Šupe Domić | Sanja Lovrić Kojundžić
Objectives Depression is characterized by a lack of energy, social withdrawal, and fatigue, and it is also associated with increased inflammation in the brain. Some studies suggest that adropin may have anti-inflammatory effects and could reduce the inflammatory processes contributing to depression. Methods: We included 54 newly diagnosed patients experiencing their first episode of depression and 56 healthy volunteers in this study. The participants with depression were divided into three subgroups based on DSM-5 and BDI-II criteria. The focus of the study was to compare adropin levels between depressive patients and healthy volunteers, as well as to monitor changes in adropin levels after six months of treatment for depressive patients. Results: Initial measurements showed no significant differences in standard laboratory parameters or adropin levels between the depression and control groups. However, adropin and vitamin D levels increased in the group of depressive patients during the six-month follow-up. Conclusions: Our research indicates that adropin plays a significant role in the development of depression and may influence the effectiveness of depression treatments.
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