Chemical Profiles and Biological Activities of Essential Oil from Serissa japonica
2025
Ty Viet Pham | Thien-Y Vu | Hien Minh Nguyen
This study was the first to analyze the chemical compositions and bioactivities of Serissa japonica leaf oil. The oil, obtained via hydro-distillation with a 0.1% yield, contained 64 compounds, predominantly non-terpenic compounds (39.0%), oxygenated sesquiterpenes (31.4%), and oxygenated monoterpenes (25.6%). Major constituents included 1,8-cineole, (E)-nerolidol, and iso-longifolol. The oil showed good antioxidant activity (IC50 &asymp: 62.79 ±: 0.77 µ:g/mL for DPPH and 57.82 ±: 1.12 µ:g/mL for ABTS) and a good anti-tyrosinase effect (IC50 &asymp: 195.6 ±: 3.82 µ:g/mL). The trend was similar to anti-inflammatory activity, with an IC50 value of 63.03 ±: 3.22, for NO inhibition without cytotoxicity at 100 µ:g/mL. The bovine serum albumin (BSA) blocking assay demonstrated an IC50 value of 59.31 ±: 0.71 µ:g/mL, indicating a good interaction regarding enzyme inhibition. Moreover, the computational modeling of the possible association between tyrosinase and cyclooxygenase-2 highlighted their antioxidant and anti-inflammatory properties. The results pointed out the usefulness of S. japonica essential oil as a natural candidate for managing oxidative stress and inflammation.
显示更多 [+] 显示较少 [-]