Large-Scale Solvent-Free Chlorination of Hydroxy-Pyrimidines, -Pyridines, -Pyrazines and -Amides Using Equimolar POCl3
2012
Han Wang | Kun Wen | Le Wang | Ye Xiang | Xiaocheng Xu | Yongjia Shen | Zhihua Sun
Chlorination with equimolar POCl3 can be efficiently achieved not only for hydroxypyrimidines, but also for many other substrates such as 2-hydroxy-pyridines, -quinoxalines, or even -amides. The procedure is solvent-free and involves heating in a sealed reactor at high temperatures using one equivalent of pyridine as base. It is suitable for large scale (multigram) batch preparations.
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书目信息
出版者
Molecular Diversity Preservation International
页码
p.4533-4544
其它主题
Solvent-free; Phosphorous oxychloride (pocl3)
语言
英语
类型
Journal Article
2025-07-18
2025-10-23
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