Bactrocera zonata (Saunders) flies are the dangerous insect pests of fruit, vegetables, and nuts over the world. This study provides the published information on toxicity, biochemical effects and some biological measurements of the peach fly, B. zonata by using some plant extracts (phytochemicals) namely Moringa oleifera oil, lemon peel oil and M. oleifera leaf extract, which would be more informative for publication facilitating related to integrated pest management (IPM) strategies of B. zonata. Effect of different concentrations of M. oleifera oil, lemon peel oil and M. oleifera leaf extract on biochemical effects (total proteins, total carbohydrates and acetylcholine esterase enzyme) and some biological aspects (pupal mortality, pupal duration, adult emergence, emerged deformed adult and malformation score) of the peach fly, B. zonata were studied. Results showed that M. oleifera oil is highly toxic to pupae of the peach fly, B. zonata with LC50 of 2.569, 2.773 and 2.370 ml/L and LC90 of 85.459, 92.171 and 18.314 ml/L in yellow, sandy and clay soils respectively. Whereas lemon peel oil come in the second position in order of toxicity and M. oleifera leaf extract was the least toxic compound. These results cleared that concentrations of total proteins, total carbohydrates and acetylcholine esterase enzyme activity markedly decreased in pupae of B. zonata after exposure to M. oleifera oil, lemon peel oil and M. oleifera leaf extract with highly significant effects compared with control. Obtained results showed that an inhibitory action of M. oleifera oil, lemon peel oil and M.oleifera leaf extract at all each of concentration levels when mixed with three types of soils namely, yellow soil, sandy soil and clay soil compared with untreated . These results suggest that three tested plant extracts has the probably to be used as a natural plant productions to control of the peach fly, B. zonata.