Our continually changing world has created new demands in society and has profoundly affected ecosystems, cultures, and professions. Ignoring the requirements and consequences of this ever-changing milieu could have devastating effects on all aspects of veterinary medicine. With the increasing global interconnections, several concepts have been created that should be addressed by the veterinary profession; otherwise, some instabilities will affect both the job and the society. In this article, these concepts will be critically analyzed and synthesized to portray an integrated perspective to address the necessities for the economic success of food animal practice, as well as describing the complicated role of veterinary medicine in the future. The first concept is the “evolving veterinary education”, introduced by OIE in 2009, to address the new requirements of competent veterinarians who are able to respond and adapt to modern trading and business requirements. The second concept is “One-Health”, which was introduced to address an integrated and all-inclusive perspective to health issues. All the specifications of this new concept are reflected in each letter of the word HEALTH (Humans, Ecosystems, Animals, Living Together, Harmoniously). The third concept is related to the “virtual water” theory, the total water consumed in the process of every activity, namely, the water footprint. It has been estimated that about 1000 and 15,500 liters of water are consumed in the process of production of a liter of milk and a kilogram of meat, respectively. Finally, the carbon footprint concept has been introduced to measure the total greenhouse gases emissions that enter into the atmosphere as carbon dioxide equivalent through individuals, events, organizations, services, places, products, and industries. The veterinary profession has a critical role and responsibility in the integration of the four abovementioned concepts.

This study aimed to investigate the effects of pomegranate seed powder on cadmium-poisoned testicular tissue in Japanese quail. A total of 270 day-old Japanese quail chicks were assigned to six treatment groups, control group, cadmium 50 ppm (group II), pomegranate seed powder (1 and 0.5 %; groups III and IV, respectively), pomegranate seed powder 1% + Cd 50 ppm (group V), pomegranate seed powder 0.5% + Cd 50 ppm (group VI). Stereological parameters in testes and TBARS, cholesterol, and triglyceride levels were determined. Testicular components showed a significant reduction in area surface and volume density in the cadmium-exposed groups compared with controls (p < 0.05). It was found that in the cadmium induction group, TBARS, cholesterol, and triglyceride levels were significantly higher compared to the normal level (p < 0.05). The results showed that pomegranate seed powder could increase the area surface and volume density of testicular germinal ingredients and decrease the content of TBARS, cholesterol, and triglyceride (p > 0.05) in cadmium poisoning testis. These results show that cadmium has destructive effects and pomegranate seed powder has prevented the development of these effects on stereological and lipid parameters.

Chlamydophila abortus is one of the major causes of pregnancy failure (abortion) in sheep and goats in many countries. In the present study, milk samples from sheep and goat herds of West Azerbaijan, Iran were examined for C. abortus using PCR and nucleotide sequencing. A total number of 360 milk samples were randomly collected from sheep (n=180) and goats (n=180) of three different regions of West Azerbaijan province during 2018. DNA was isolated from samples and the nested-PCR was employed targeting the 16S rRNA gene for detection of Chlamydia spp. The omp gene was amplified and sequenced for the characterization of detected C. abortus.The results showed that 8.61% (95% CI: 6.13%–11.96%) of the examined samples (11.67% sheep and 5.56% goat milk samples) were positive for C. abortus. The frequency of positive samples in the central region was significantly higher than in other regions. Positive samples for C. abortus from animals with a history of abortion were significantly higher than those without a history of abortion. Positive samples in autumn were significantly higher than the other seasons and also, in animals more than four years old were significantly higher than other age groups. Sheep infection was significantly higher than the goats. Phylogenetic analysis based on the helicase gene showed that two sequenced isolates clustered closely with the other C. abortus isolates reported in the GenBank. In conclusion, small ruminants in West Azerbaijan province were contaminated with C. abortus and they could shed this organism into the milk.

The current study aimed to see how the central dopaminergic and cannabinoidergic mechanisms affect melanocortin-induced food intake in the neonatal layer chickens. In this regard, 9 experiments were designed. In experiment 1, chicks injected with control solution, MTII (2.5, 5, and 10 ng). In experiment 2, control solution, L-DOPA (125 nmol), MTII (10 ng), and L-DOPA + MTII were applied to the birds. Experiments 3-9 were similar to experiment 2, except birds injected with 6-OHDA (150 nmol), SCH23390 (5 nmol), AMI-193 (5 nmol), NGB2904 (6.4 nmol), L-741,742 (6 nmol), SR141716A (6.25 µg), and AM630 (5 µg) instead of L-DOPA. Then, cumulative food intake was recorded at 30, 60, and 120 min following injection. According to the results, in comparison with the control group, dose-dependent hypophagia was observed in 3-h food-deprived neonatal layer chickens following ICV injection of MTII (2.5, 5, and 10 ng) (P<0.05). ICV injection of L-DOPA and SR141716A increased hypophagia induced by MTII in chickens (P<0.05), while 6-OHDA greatly suppressed MTII- induced hypophagia (P<0.05). In addition, SCH23390 and AMI-193 greatly weakened the MTII-induced hypophagia in neonatal layer chickens (P<0.05). However, NGB2904, L-741742 and AM630 had no role on hypophagia induced by MTII (P>0.05). These results demonstrated that melanocortin-induced hypophagia in the neonatal layer chickens is likely mediated by D1, D2, and CB1 receptors.

This study aimed to determine the influences of antioxidants additives on motility characteristics of different goat spermatozoa types including frozen/thawed, fresh, and chilled samples. Ejaculates from five Shami bucks were collected during breeding and non-breeding seasons. Spermatozoa samples from the three types were incubated in media containing 2 and 4 mM oxidized glutathione (GSSG), 5 and 10 mM L-cysteine,10 and 25 mM taurine, and no additives (control). Motility characteristics were analyzed by a computer-aided sperm analyzer (CASA). Except for taurine, the addition of antioxidants resulted in a significant (p < 0.05) increase in the percentage of motile sperm (MOT %) after spermatozoa thawing. When fresh sperm samples were collected during the non-breeding season and treated with both GSSG and L-cysteine, the values of the velocity parameters VAP, VSL, and VCL increased significantly (p < 0.05). No significant effects were noted for the velocity parameters when 10 and 25 mM of taurine were added to the chilled spermatozoa, while GSSG and L-cysteine had principally affected MOT % of this spermatozoa type. The rapid spermatozoa subpopulation was the most influenced category by the three antioxidants compared to the slow and medium grades, especially in the case of fresh and frozen/thawed types. In conclusion, the effects of different antioxidants on goat spermatozoa motility largely depend on the used concentration and also on the type of spermatozoa pattern.

A two-year-old queen was referred to the surgery section of veterinary hospital with lateral recumbency position and the primary diagnosis of dystocia. The queen was highly lethargic and dehydrated, with a pale mucous membrane, a rectal temperature of 37.3 °C, and no vaginal discharge during first inspection. The primary examination revealed a big mass in the abdominal cavity, which was followed by other diagnostic investigations. Due to a huge and encroaching tumor and the patient's owner's refusal to accept any further therapies, the queen was euthanized during an exploratory celiotomy. This report describes a large Hemangiopericytoma (HPCy) in a domestic short-haired queen diagnosed based on physical examination, radiography, ultrasonography, histomorphology, and immunohistochemical reactivity. The results of pathology revealed a whorls around blood vessels and the "fingerprint" pattern of tumor with negative S-100 immunohistochemistry staining.   In dogs, HPCy is a common neoplasm, but it is a seldom finding in cats. There is no previous report of HPCy in the abdominal cavity as observed in the presented case to the authors' knowledge.

Mesenchymal Stem/Stromal Cells (MSCs) have been applied to modulate various immune-mediated conditions. Prolonged culture of MSCs in vitro reduces their therapeutic efficacy. Pretreatment of the cells with some chemical agents during in vitro expansion could overcome this limitation. This study intended to determine whether pretreatment of adipose-derived MSCs (ASCs) with Human chorionic gonadotrophin (hCG), a glycoprotein hormone, and Vitamin E, an antioxidant, will improve their immunomodulatory ability. In this regard, ASCs were harvested from human processed lipoaspirate. LPS-induced ASCs were preconditioned with 1 mg of hCG and 600 µM of vitamin E for 24h. TSG-6, COX-2, IL-1β, and IL-6 were assessed at the mRNA level in preconditioned and control groups. ASCs were also co-cultured with peripheral blood mononuclear cells (PBMCs) in vitro to determine the functionality of these cells. Results showed that hCG and vitamin E significantly downregulate the pro-inflammatory COX-2, IL-1β, and IL-6 gene expression, while they did not significantly increase TSG-6 expression. Besides, the co-culturing of pretreated ASCs with PBMCs demonstrated that the amount of PBMCs in treated groups (with hCG and vitamin E) was significantly lower than in control groups. These findings revealed that the preconditioning of ASCs with hCG and vitamin E might enhance their immunoregulatory capacity.

Trypanosomosis is an economically important disease that has raised great and diverse kinds of research using different types of animals. Hence, this study is aimed at determining the better laboratory animal between the Swiss albino mice and Wistar albino rats in Trypanosoma brucei brucei studies. This study assessed the pathogenesis of T. b. brucei in Swiss albino mice and Wistar albino rats by probing the level of parasitemia, mean temperature, mean weight, hematological and histopathological parameters caused by the hemoprotozoan. Twenty laboratory animals, of mice (10) and rats (10) were grouped in two (control (5) and infected (5)), with the infected group inoculated with the blood protozoan intraperitoneally. Trypanosoma b. brucei was detected in the blood of both laboratory animals on day one post-infection, with all the infected animals dying between day seven and eight post-infection. The protozoan exerted a significant (p < 0.05) effect on the mean temperature, mean weight, and hematological parameters of the infected animals. Pathological effects of T. b. brucei infection were seen in the liver and lungs of mice, and the liver, lungs, kidney and spleen of rats. The pathogenesis of T. b. brucei was more severe in rats compared to mice based on the studied parameters. These findings showed that rats are better candidates for T. b. brucei studies.

< p>< p>The present study aimed to evaluate the efficacy of different hormonal interventions in the treatment of cystic ovarian follicles (COF) based on different scenarios, including the size of the cyst and the presence of other follicles on the ovaries of dairy cows. A total of 199 Holstein cows with COF in the first 100 days postpartum were enrolled in the study. These cows were randomly assigned to the four following groups: 1) GnRH (G) group: intramuscular (IM) injections of 100 µg gonadorelin acetate on day 0 and 150 µg d-cloprostenol 7-12 days later, 2) double GnRH (DG) group: two IM injections of 100 µg gonadorelin acetate at 6 h intervals on day 0 and d-cloprostenol 7-12 days later, 3) intravaginal progesterone device (IPD) group: insertion of PRID Delta for 7-12 days and injection of d-cloprostenol on the withdrawal of PRID Delta, and 4) control group: IM injection of 2 mL sterile saline on day 0 and 7-12 days later. The cure rate of COF significantly improved in the G and DG groups, in comparison with the IPD and control groups. There was no significant difference between the cows in the G and DG groups. In the control group, animals with ovarian cysts smaller than 2.5 cm had a significantly greater self-cure rate, compared to the other cows. In conclusion, this field study demonstrated a good clinical cure in the groups of cows treated by GnRH. However, no improvement was observed in the reproductive performance of these animals.

This study was carried out to investigate the causative agents of the parasitic diseases affecting common carp (Cyprinus carpio) in aquacultures in the Erbil region. At first, all fish were visually examined, then, microscopic analysis of mucus, skin and fins scrapings and gastrointestinal contents were carried out, confirming that carps are infested by a large diversity of parasites,  predominantly affected by  Dactylogyrus sp., followed by Trichodina sp., and copepod parasites, with an infection rate of 25.2%,  17.2%, and 13.2%, respectively. On the other hand, the highest mortality was due to infestation by Trichodina sp., Dactylogyrus sp., Ichthyophthirius sp. and Gyrodactylus sp., rating 40%, 35%, 29% and 28%, respectively. Several injuries and ulcerations were observed within gills, over fins and skin of infected fish. In conclusion, the results showed that carp fish from Erbil city are infested by several parasites causing pathological and mechanical injuries, which were associated with high mortality rates in carps.