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Morphological evaluation on the effect of panaxadiol series ginsenosides in irradiated mice
Lee, H.J.;Kim, S.R.;Kim, S.H.(Chonnam National University, Gwangju, Republic of Korea)E-mail:shokim@chonnam.ac.kr
The purpose of the study was to investigate the effect of ginseng saponins (panaxadiol, ginsenoside Rb₁, Rb₂, Rc, Rd) on jejunal crypt survival, endogenous spleen colony formation and apoptosis in jejunal crypt cells of mice irradiated with gamma-ray. ICR mice were given each saponin (i.p. 50 mg/kg of body weight) at 24 hours before irradiation. The radioprotective effects of saponins were compared with the irradiation control respectively. The jejunal crypts were protected by pretreatment with ginsenoside Rc (p less than 0.05) and Rd (p less than 0.05). The spleen colony was increased by pretreatment with panaxadiol (p less than 0.05) and ginsenoside Rd (p less than 0.05).
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