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Influence of tolazoline on caudal epidural administration of xylazine in cattle.
1990
Skarda R.T. | St Jean G. | Muir W.W. III
Eight adult female cattle (6 Holstein, 1 Jersey, 1 Brown Swiss) were used to determine the antagonistic effects of tolazoline, an alpha 2-adrenoceptor antagonist, on xylazine-induced (via caudal epidural administration) depression of CNS, respiratory, and cardiovascular activity and rumen motility. A 2% solution of xylazine HCl was injected into the epidural space at the first coccygeal interspace, using a dosage of 0.05 mg/kg of body weight, diluted to a 5-ml volume with sterile water, and administered at a rate of approximately 1 ml/30 s. Eight minutes after xylazine injection, either tolazoline (0.3 mg/kg) or saline solution (4 ml) was administered IV. All 8 cattle were treated, using both regimens in a random sequence; at least 1 week elapsed between treatments. Epidurally administered xylazine induced caudal analgesia (S3 to coccyx), as evaluated by no response to superficial and deep muscular pinprick, and induced sedation, cardiopulmonary depression, and inhibition of rumen motility, but all cattle remained standing. Tolazoline effectively reversed xylazine-induced rumen hypomotility, and partially antagonized xylazine-induced cardiopulmonary depression without affecting sedation and desirable local (S3 to coccyx) analgesic effects.
显示更多 [+] 显示较少 [-]Antagonism of xylazine-induced hypotensive effect by yohimbine in rabbits.
1990
Shin D.H.
Effect of yohimbine and 4-aminopyridine on gastroduodenal transit time in xylazine-pentobarbital-anesthetized dogs
1990
Kim, D.J. | Choi, M.C. | Sung, J.K. (Seoul National University, Suwon (Korea Republic). College of Veterinary Medicine)
