BACKGROUND: In the past decades, medicinal plants were used to enhance the specific and non-specific defense mechanism and to increase resistance to disease. OBJECTIVES: This study was performed to evaluate the effect of Curcuma longa L. on the hematological factors of Huso huso. METHODS: In this study, 90 beluga with average weight of 2.403± 0.006 Kg were kept on Shahid Rajai reproduction, culture and rehabilitation of sturgeon for 20 days. This number of fish were distributed in the three groups with the names curcumin, control (+) and control (-) with three replicates. After one week adaptation with experimental environment fish were injected intraperitoneally. In curcumin group 400 mg/kgbw curcumin extract at the maximum volume of 0.5 ml was used. In control (+)and in control (-) without injection 0.5 ml of physiological serum was kept just to check fish experimental conditions. Blood was taken at 0, 3, 6, 9 and 12 days post injection. RESULTS: The results of this study showed that the amount of red blood cells, white blood cells, hematocrit, hemoglobin and blood indices such as MCV, MCH, MCHC in the curcumin group was higher  than the control group (control (+) and control (-)). CONCLUSIONS: The result of this study showed that use of curcumin in beluga has high impact on increasing Hematology parameters.