The present study assigns the effect of neuroectomy to bone healing of experimentally induce bone fracture in 3rd metacarpal bone ,in donkeys by macroscopic, radiographic and evaluation of mineral levels(ca,p). Sixteen donkeys of male sex with the age 1.5- 2 years, weighting 125-150 kg. were used for this study. These animals were healthy clinically. The donkeys were divided randomly into two groups( non- neuroectomized and neuroectomized) eight donkeys each group. The animals anaesthetized with xylazine Hcl at dose 0.5 mg/kg. B.W., then injectable Ketamine Hcl at the dose 3 mg/kg B.W.which administered intravenously. The animals of non- neuroectomized group, induced one fracture at the mid of the shift of 3rd metacarpal bone. Evaluated with clinical signs macroscopical, estimation of level of mineral and radiographic examination. Gross examination swelling in the site of fracture and lameness. The callus formation shows in radiographic examination.The calcium concentration was highly significant increase after 30th and 60th days , which the phosphorus level increase after 30th days and then s decrease at 60th days

Objective—To evaluate effects of long-term administration of carprofen on healing of a tibial osteotomy in dogs. Animals—12 healthy female Beagles. Procedures—A mid-diaphyseal transverse osteotomy (stabilized with an intramedullary pin) of the right tibia was performed in each dog. The carprofen group (n = 6 dogs) received carprofen (2.2 mg/kg, PO, q 12 h) for 120 days; the control group (6) received no treatment. Bone healing and change in callus area were assessed radiographically over time. Dogs were euthanized 120 days after surgery, and tibiae were evaluated biomechanically and histologically. Results—The osteotomy line was not evident in the control group on radiographs obtained 120 days after surgery. In contrast, the osteotomy line was still evident in the carprofen group. Callus area was significantly less in the carprofen group, compared with the area in the control group, at 20, 30, and 60 days after surgery. At 120 days after surgery, stiffness, elastic modulus, and flexural rigidity in the carprofen group were significantly lower than corresponding values in the control group. Furthermore, histologic evaluation revealed that the cartilage area within the callus in the carprofen group was significantly greater than that in the control group. Conclusions and Clinical Relevance—Long-term administration of carprofen appeared to inhibit bone healing in dogs that underwent tibial osteotomy. We recommend caution for carprofen administration when treating fractures that have delays in healing associated with a reduction in osteogenesis as well as fractures associated with diseases that predispose animals to delays of osseous repair.