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Involvement of nervous system in cattle and buffaloes due to Pasteurella multocida B:2 infection: A review of clinicopathological and pathophysiological changes
2015
Ali Dhiaa Marza | Faez Firdaus Jesse Abdullah | Ihsan Muneer Ahmed | Eric Lim Teik Chung | Hayder Hamzah Ibrahim | Mohd Zamri-Saad | Abdul Rahman Omar | Md Zuki Abu Bakar | Abdul Aziz Saharee | Abdul Wahid Haron | Mohd Azmi Mohd Lila
Hemorrhagic septicemia (HS) is an acute septicemic disease principally affecting cattle and buffaloes caused by specific serotypes B:2 and E:2 of Pasteurella multocida in Asia and Africa, respectively. Despite continuing researches on pathogenesis of P. multocida for several decades, the mechanisms by which these bacteria develop the diseases are poorly understood. Although the involvement of the nervous system in the disease progress of HS is rare under natural conditions, few reports indicated the involvement of the nervous system in outbreaks of HS in cattle and buffaloes. Additionally, recent pathogenesis studies in both mouse and buffalo experimental models reported the involvement of nervous system due to P. multocida B:2, with bacteriological and histopathological evidences. In this review, we summarized and discussed the updates on the involvement of the nervous system in pathogenesis of HS focusing on clinical signs, pathological and pathophysiological changes. [J Adv Vet Anim Res 2015; 2(3.000): 252-262]
显示更多 [+] 显示较少 [-]Anti-inflammatory effects of 4 ,4 -diaminodiphenyl sulfone (dapsone) in lipopolysaccharidetreated spleen cells: selective inhibition of inflammation-related cytokines
2015
Moon, S.Y., Laboratory of Veterinary Pharmacology, College of Veterinary Medicine, Jeju National University, Jeju, Republic of Korea | Joo, H.G., Laboratory of Veterinary Pharmacology, College of Veterinary Medicine, Jeju National University, Jeju, Republic of Korea
4 , 4 - diaminodiphenyl sulfone (dapsone) is a sulfone drug that has antibacterial effects on a variety of bacteria, especially Mycobacterium leprae ; thus, it has been used to treat leprosy. Previous studies demonstrated that dapsone inhibits integrin-mediated adherence of neutrophils and production of prostaglandin E2 by polymorphonuclear leukocytes. Hence, dapsone may act in immune cells and regulate cell-mediated inflammation processes. However, its antiinflammatory effects remain unclear. The present study demonstrated that dapsone modulates the production of inflammation-related cytokines in immune cells. We employed the spleen cells of mice, which are major immune cells, and lipopolysaccharide (LPS) as a causative agent of inflammation for experiments. Dapsone induced a proportional change in splenocyte subsets and the apoptosis of spleen cells. Interestingly, dapsone decreased the production of tumor necrosis factor-alpha and interleukin (IL)-10, but not IL-6, in LPS-treated spleen cells. In other assays, we measured the dapsone-induced production of nitric oxide (NO) and the expression of activation markers of spleen cells. Dapsone decreased NO production in LPS-treated spleen cells. Taken together, our results demonstrate that dapsone has antiinflammatory effects in immune cells and provide new insight into the potential uses of this agent.
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