In the conditions of the Republic of Belarus there was produced a trial series of hyperimmune serum against livestock animals colibacillosis and there was realized the quality control of the analysed biological preparation. Research results proved that the developed serum was sterile, safe and had high immunogenetic activity. In course of quality control there were considered the following indexes: determination of physiognomy, colour, presence of visually accessible particulate matters; determination of safety and harnfullness; determination of activity; determination of concentration of hydrogen ions; determination of sterility; determination of serum volume in consumption package. For serum production there were used strains E.coli O9, O78, O0, O117, O26, O139, O15, O41, O55, O115, O141, O8, K88, K99, F41, 987P. For the production of trial series there was realized cultivation of Escherichia on the special nutritive media. There used bulls as serum producers

Research of immune activity of an experimental series of inactivated vaccine against swine pasteurellosis (Pasteurella) with application of adjuvants of Sepptic Montanida ISA 70 and Montanida ISA 206 was realized in the conditions of the Republic of Belarus. In the capacity of water phase there were used serovars A, B, and D Pasteurella multocida. Research results proved the possibility of application of adjuvants of Sepptic company for the development of vaccine against pasteurellosis. The vaccine with the presented adjuvants after its application did not cause after-trouble effects. In course of immunization there was noted the formation long-lived continuous immunity that was proved by high titres of specific anti-bodies in blood serum in all experimental groups of piglets. Single application of the proposed vaccine in doses 2 or 3 ml per animal proved to be effective. Also it was efficient to apply it twice in doses 1 and 2 ml per animal. For the vaccine production it was proposed to use adjuvant Montanida ISA 206 which did not have high reactogenicity

Analysis of the epizootological situation in infectious diseases in the world and the Republic of Belarus was presented. The prevention and eradication control strategy of mentioned diseases in Belarus was defined. In Belarus there was stated no cases of special danger infectious diseases of cattle: bovine spongiform encephalopathy; highly pathogenic poultry flu; aphthous fever; since 1982 - Bang's disease; since 1980 - Newcastle disease; since 1999 – anthrax. Preventive maintenance of 30 infectious diseases was based on application of specific prophylaxis.

Usage of biological preparation of high antibacterial activity allows to decrease the air pollution by bacteria of colon bacillus group at 25-100%, increase productivity at 17-67 g, safety – at 0,4%, resistance, protein metabolism, protein fractions and some other indices (lysozyme and betalysine activity, leucocytes, erythrocytes, hemoglobin, calcium, phosphorus, iron, magnesium, AST, ALT, urea, cholesterol, bilirubin and glucose)

Analysis of manifestation of chlamydial infection of cattle in the conditions of forage affect with mycotoxins was realized in the conditions of the Republic of Belarus. Research results showed that chlamydial infection proceeded in association with aflatoxin, T-2 toxin, deoxynivalenol, zearalenone and ochratoxin. In course of the biochemical analysis there was noted the lowering of carotene on 23%, and vitamin A – in two times; also there was slight lowering of alkaline reserve. The obtained data proved the substantial changes in content of sub-populations of lymphocytes in cow blood in dry and postnatal period. During the immunological study of immunoglobulins in blood serum of cows sick with postpartum chlamydial endometritis it was revealed that titre of immunoglobulin A was on 31% higher. Level of immunoglobulins G and M differed slightl