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A novel biomarker of exercise-induced stress in horses
2015
Lee, S., College of Veterinary Medicine, BK21plus Program for Creative Veterinary Science Research, and Research Institute for Veterinary Science, Seoul National University, Seoul, Republic of Korea | Oh, D., College of Veterinary Medicine, BK21plus Program for Creative Veterinary Science Research, and Research Institute for Veterinary Science, Seoul National University, Seoul, Republic of Korea | Kim, M.C., College of Veterinary Medicine, BK21plus Program for Creative Veterinary Science Research, and Research Institute for Veterinary Science, Seoul National University, Seoul, Republic of Korea | Kim, Y., College of Veterinary Medicine, BK21plus Program for Creative Veterinary Science Research, and Research Institute for Veterinary Science, Seoul National University, Seoul, Republic of Korea | Ryu, D.Y., College of Veterinary Medicine, BK21plus Program for Creative Veterinary Science Research, and Research Institute for Veterinary Science, Seoul National University, Seoul, Republic of Korea
Exercise is one of the most common stressors in horses. Although various physiological parameters such as cortisol respond to exercise, there is no reliable parameter for the measurement of exercise-induced stress in sport horses. This study was performed to discover a new biomarker with high sensitivity for exercise-induced stress. The expression of fos mRNA was increased more than 10-fold in horse blood samples collected after an hour of exercise, as compared with before the exercise. The plasma cortisol levels were also increased after the exercise, but only by about two-fold. The fos mRNA levels were well-correlated with plasma cortisol concentrations. These findings suggest that fos mRNA expression in blood may be useful for the measurement of exercise-induced stress in horses.
显示更多 [+] 显示较少 [-]The relationship between high glucose-induced secretion of IGFs and PKC or oxidative stress in mesangial cells
Park, S.H.;Heo, J.S.;Han, H.J.(Chonnam National University, Gwangju, Republic of Korea)E-mail:hjhan@chonnam.ac.kr | Kang, C.W.(Chonbuk National University, Jeonju, Republic of Korea)
The proliferation of mesangial cells has been associated with the development of diabetic nephropathy. The cell proliferation has been regulated by diverse growth factors. Among them, insulin like growth factors(IGFs) are also involved in the pathogenesis of diabetic nephropathy. However, it is not yet known about the effect of high glucose on IGF-I and IGF-Ⅱ secretion and the relationship between high glucose-induced secretion of IGFs and PKC or oxidative stress in the mesangial cells.
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