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Mouse (Mus musculus) embryonic cerebral cortex cell death caused by carbofuran insecticide exposure 全文
2019
Luqman, Epy Muhammad | Sudiana, I Ketut | Darmanto, Win | Achmad, Agung Budianto | Widjiati,
Mouse (Mus musculus) embryonic cerebral cortex cell death caused by carbofuran insecticide exposure 全文
2019
Luqman, Epy Muhammad | Sudiana, I Ketut | Darmanto, Win | Achmad, Agung Budianto | Widjiati,
The aim of the study was to describe the process of neuron death in the cerebral cortex caused by embryonic carbofuran exposure. 81 mouse foetuses from 27 breeding mice were used in the study. Carbofuran was administered by gavage from the 6ᵗʰ to the 15ᵗʰ day of gestation to two groups: one at 0.0208 and the other at 0.0417 mg/kg b.w. On the 17ᵗʰ day, the mice were sacrificed and the foetuses were taken to measure the ROS (malondialdehyde/MDA and superoxide dismutase/SOD) activity in brain tissue, the number of apoptotic embryonic cerebral cortex neurons using a TUNEL assay, and necrotic cells using HE staining. Examination of p53 and caspase 3 expression was done by immunohistochemistry. Data were analysed using analysis of variance (ANOVA) and Duncan’s test. Increased activity of cerebral ROS characterised by significant elevation of the MDA level (P < 0.05), decreased SOD (P < 0.01), increased p53 and caspase 3 expression, and cerebral cortical neuron death either by necrosis or apoptosis (P < 0.05) were found. At the low dose carbofuran increased expression of p53, caspase 3, and apoptosis. At the high dose it increased levels of MDA and necrosis. Increased expression of p53 and caspase 3 and apoptosis indicated that carbofuran may cause apoptosis through the intrinsic pathway. The increased apoptosis grants an opportunity to prevent and treat the effect of ROS due to gestational carbofuran exposure.
显示更多 [+] 显示较少 [-]Mouse (Mus musculus) embryonic cerebral cortex cell death caused by carbofuran insecticide exposure 全文
2019
Luqman Epy Muhammad | Sudiana I Ketut | Darmanto Win | Achmad Agung Budianto | Widjiati
The aim of the study was to describe the process of neuron death in the cerebral cortex caused by embryonic carbofuran exposure.
显示更多 [+] 显示较少 [-]CONCEPTUAL AND THEORETICAL PORTRAITS OF THE INCUBATION ACTIVITIES OF VETERINARY INCUBATION FOUNDATION (VIF) @ TANUVAS 全文
2024
C. Soundararajan | R. Vadivel
Incubation centers are providing office spaces, access to advanced laboratory setups, farm facilities, clinical spaces, and comprehensive mentorship encompassing technical, legal, and financial guidance to the incubatees. The activities of VIF @ TANUVAS regarding areas of interest of 62 incubatees, products and productization, grants, ideas, and awareness programs were analysed for the period from 2019 to 2023. Among the area of interest of the incubatees, most of the incubatees (85 %) are working in the domain of Veterinary while 15% of the incubatees are working in the area of life sciences. Among the Veterinary related ideas, the majority of incubatees are interested in doing research in the development of diagnostic kits 26.41%, followed by Feed and Feed supplements (24.52%) whereas life sciences-related ideas are majorly chosen for drug discovery. Out of 62 ideas, 23 products were developed with a percentage of 37.1. Out of these 13 incubatees, 5 received grants (38.46%) from the Government of India (Central funds), while the remaining 8 (61.54%) received funding from the Government of Tamil Nadu (State funds). The highest number (52.81%) of ideas obtained during the year 2023 followed by 27.3% during 2021, 10.45% during 2020, and 9.41% during 2022 with more ideas from Madras Veterinary College, Chennai. This study concludes that The outcome of the product is directly proportionate to their ideas.
显示更多 [+] 显示较少 [-]CONCEPTUAL AND THEORETICAL PORTRAITS OF THE INCUBATION ACTIVITIES OF VETERINARY INCUBATION FOUNDATION (VIF) @ TANUVAS 全文
2024
C. Soundararajan | R. Vadivel
Incubation centers are providing office spaces, access to advanced laboratory setups, farm facilities, clinical spaces, and comprehensive mentorship encompassing technical, legal, and financial guidance to the incubatees. The activities of VIF @ TANUVAS regarding areas of interest of 62 incubatees, products and productization, grants, ideas, and awareness programs were analysed for the period from 2019 to 2023. Among the area of interest of the incubatees, most of the incubatees (85 %) are working in the domain of Veterinary while 15% of the incubatees are working in the area of life sciences. Among the Veterinary related ideas, the majority of incubatees are interested in doing research in the development of diagnostic kits 26.41%, followed by Feed and Feed supplements (24.52%) whereas life sciences-related ideas are majorly chosen for drug discovery. Out of 62 ideas, 23 products were developed with a percentage of 37.1. Out of these 13 incubatees, 5 received grants (38.46%) from the Government of India (Central funds), while the remaining 8 (61.54%) received funding from the Government of Tamil Nadu (State funds). The highest number (52.81%) of ideas obtained during the year 2023 followed by 27.3% during 2021, 10.45% during 2020, and 9.41% during 2022 with more ideas from Madras Veterinary College, Chennai. This study concludes that The outcome of the product is directly proportionate to their ideas.
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