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Radiologic, Ultrasonic and pathological assessments of locally applied estrogen on promotion of experimentally induced tibial fracture healing in rats
2020
Kotb, M. M. A1 | Ragab, G. A.2 | Fathy, M. Z .2 | Haggag, U.2 | Nesreen. M. Safwat3
The objective of the present study was to evaluate the ability of estrogen to promote induced tibial fracture healing in a rat model. The study was conducted on 14 albino rats divided into two equal groups (seven rats in each group). The first group considered as a control group. The second group was injected estradiol solution 0.1 mg/kg into the fracture gap. The progress of healing in each group was evaluated by clinical, radiography, ultrasonography and pathological examinations. The healing process was observed to be superior in the estrogen group compared to the control one. Estrogen was found to promote healing of injured bone and is suggested to be used in cases of complicated or delayed bone fracture.
显示更多 [+] 显示较少 [-]Comparing open wound measuring methods popularly used in experimental studies
2015
Ciciane Pereira Marten Fernandes | Thiago Vaz Lopes | Sabrina de Oliveira Capella | Eduardo Garcia Fontoura | Mariana Teixeira Tillmann | Samuel Rodrigues Félix | Márcia de Oliveira Nobre
Tissue repair is a response reaction to lesions and aggressions that constitutes a dynamic process to maintain the integrity of the organism. Wound healing experiments have used several approaches in order to assess and compare treatment methods, and these discrepancies hamper comparisons among assays. This study assessed three different methods of wound measurement commonly used in healing assays: clock method, graph paper method, and computer-assisted image analysis. We used 30 Wistar rats, kept in appropriate conditions for animal well-being. After anesthesia, and using an eight-millimeter punch, two lesions were made in the back region of each rat. The wounds were assessed on days four, seven, and 14 after infliction. At four days, all methods generated similar results. By day seven, the clock method had lost precision, likely due to wound shrinkage, and yielded greater means compared to the other two methods. On the last assessment, the computer-assisted method appeared to have more precise results, with the other two generating statistically higher means. Computer-assisted image analysis seems to have maintained wound measuring precision throughout this experiment, even when faced with small lesions. Considering these results, the authors recommend the use of computer-assisted measurements in future experiments.
显示更多 [+] 显示较少 [-]Use of a porous cellulose membrane (Membracel®) and moxibustion for severe excoriative injury in a chilean skua (Catharacta chilensis)
2018
Natassia Bacco Mannina | Daniela Magalhães Drummond de Mello | Priscilla Carla dos Santos Costa | João Paulo Bastardo Rodrigues | João Victor da Silveira Bertão
The use of alternative therapeutic approaches in wild animals has gained notoriety due to its efficiency, low cost and reduced or nonexistent stressors. The present study evaluated the efficacy of treatment of a bilateral excoriative lesion in the region of the dorsal metacarpus in a Chilean skua (Catharacta chilensis) in a rehabilitation process with the use of a porous cell membrane, sold commercially, in concomitance with moxibustion sessions with herbs (Artemisia vulgaris). The healing time of 14 days was reduced when compared to traditional techniques and proved the viability and efficacy of the treatment.
显示更多 [+] 显示较少 [-]Experimental skin wound treatment with Copaifera langsdorffii Desf Kuntze (Leguminosae) extract and oil-resin in horses
2020
Débora Perrone Kauer | Juliana de Moura Alonso | Lucas Fernando Sergio Gushiken | Marivane Lemos | Carlos Roberto Padovani | Celso Antonio Rodrigues | Ana Liz Garcia Alves | Marcos Jun Watanabe | Jairo Kenupp Bastos | Cláudia Helena Pellizzon | Carlos Alberto Hussni
Copaifera langsdorffii is a Brazilian native plant that is used for wound healing or as an anti-inflammatory agent. Non-healing wounds are an important health problem, particularly in horses, because they can cause the animal invalidity or even lead to death. In addition, horses respond to skin wounds with chronic inflammatory response and intense wound granulation, thereby delaying the healing process. By this way, our aim was to evaluate the healing potential of Copaifera langsdorffii hydroalcoholic extract (HE) and oil-resin creams (OR) in horse skin wounds. Four wounds were performed bilaterally in the lumbar region of six horses with a 2 cm punch and treated daily with the respective treatments: saline solution, vehicle, 10% HE creams or 10% OR cream. Daily planimetry analyses were performed to measure the wound area and clinical parameters. In four different experimental periods (3, 7, 14 and 21 d), wound biopsies were removed and used for microscopic analyses. SS wounds presented a significant small area at day 3 and 7, OR wounds presented significant small area in comparison with HE at 14 d, and no significant difference was observed between treatments at 21 d. A better microscopic and clinical healing activity of HE and OR was identified in comparison with the controls. The OR group showed better healing quality, specifically after 7 d of treatment. Therefore, Copaifera langsdorffii formulations demonstrated their wound healing potential in horse skin lesions, exhibiting an improvement of the macro- and microscopic parameters.
显示更多 [+] 显示较少 [-]Radiologic, Ultrasonic and pathological assessments of locally applied Chitosan on promotion of experimentally induced tibial fracture healing in rats
2020
Kotb, M. M. A1 | Ragab, G. A.2 | Fathy, M. Z.2 | Haggag, U.2 | Nesreen M. Safwat3
The objective of the present study was to evaluate the ability of Chitosan to promote induced tibial fracture healing in a rat model. The study was conducted on 14 albino rats divided into two equal groups (seven rats in each group). The first group was considered as a control group. The second group was injected Chitosan solution 0.1 mg/kg into the fracture gap. The progress of healing in each group was evaluated by clinical, radiography, ultrasonography and pathological examinations. The healing process was observed to be superior in the Chitosan group compared to the control one. Chitosan was found to promote healing of injured bone and is suggested to be used in cases of complicated or delayed bone fracture.
显示更多 [+] 显示较少 [-]Evaluation of Locomotor and Morpho-histological Effect for Platelet Rich Plasma and Silver Nanoparticles on Healing Process of Achilles Tendon (Comparative Experimental Study in Rabbits)
2023
Mohamed H. Elrashidy | Mohamed M.A. Salama | Bahaa Eldeen A. Abedellaah | Fatma Abo Zakaib Ali | Sayed F. El-Hawari
Tissue engineering is a new treatment option provided encouraging results in orthopedic surgery. In the present study, we compare between platelet rich plasma (PRP) and silver nanoparticles (AgNPs) in the healing process of achilles tendon. This comparison depending upon the evaluation of locomotor and morpho-histological parameters for each treatment. The current study was carried out on 45 apparently healthy adult female rabbits. Locomotor evaluation was done through numerical score at intervals of 2, 4, 6 and 8 weeks postoperatively. Morpho-histological evaluation was performed through numerical score at intervals of 2, 3 and 6 weeks postoperatively. Results of the current study revealed that PRP and AgNPs were better than control group regarding to lameness, pain on complete flexion of tarsal joint, adhesion of tendon to the skin and signs of inflammation. However, PRP is better than both control and AgNPs groups in decreasing lameness and adhesion of tendon to the skin. Morpho-histological examination revealed that PRP is better than both control and AgNPs in improving color of the tendon. PRP and AgNPs were better than control group concerning collagen maturation, fibroblast number, angiogenesis, and surgical gap reduction. However, PRP is better than both control and AgNPs in decreasing signs of inflammation and increasing collagen maturation. We concluded that using PRP for treatment of ruptured achilles tendon provides better prognosis than AgNPs treatment.
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