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Immune response of cattle to Haemophilus somnus lipid A-protein conjugate vaccine and efficacy in a mouse abortion model.
1992
Inzana T.J. | Todd J.
Immunogenicity of the lipid A component of Haemophilus somnus lipooligosaccharide in cattle and mice was examined after purification, detoxification, and covalent conjugation to a protein carrier. After 2 inoculations, a substantial antibody response was induced in most cattle to lipid A and the protein carrier. To determine whether antibodies to lipid A would be protective, 5 X 10(7) colony-forming units of H somnus strain 649 were administered IV to endotoxin-responsive (C3H/HEN) mice. In one study, 8 of 13 C3H/HEN mice aborted when inoculated. In contrast, abortion did not result when mice were inoculated with the same dose of an isolate of H somnus normally found in the prepuce or with the rough mutant Escherichia coli J5. In addition, endotoxin-nonresponsive (C3H/HeJ) mice were significantly (P = 0.03) more resistant to abortion by strain 649 than were C3H/HeN mice, but inoculated C3H/HeN mice were only slightly more resistant to H somnus abortion, compared with control mice. Although a large antibody response to lipid A was detected, there was no significant difference in the immunized group between mice that aborted and mice that delivered normally. Thus, lipooligosaccharide and other properties of virulent H somnus strains may contribute to abortion in mice.
显示更多 [+] 显示较少 [-]Use of a toxoid vaccine to protect goats against intradermal challenge exposure to Corynebacterium pseudotuberculosis.
1986
Brown C.C. | Olander H.J. | Biberstein E.L. | Morse S.M.
Demonstration of vaccine-induced immunity to anaplasmosis without induction of persistent postvaccinal complement-fixing and agglutinating antibodies in yearling steers.
1985
Corrier D.E. | Johnson J.S. | Wagner G.C.
Efficacy of a streptomycin-dependent, live Pasteurella haemolytica vaccine against challenge exposure to Pasteurella haemolytica in cattle.
1987
Blanchard Channell M.T. | Ashfaq M.K. | Kadel W.L.
Second-generation pseudorabies virus vaccine with deletions in thymidine kinase and glycoprotein genes.
1987
Kit S. | Sheppard M. | Ichimura H. | Kit M.
Mortality in swine herds endemically infected with Haemophilus pleuropneumoniae: effect of immunization with cross-reacting lipopolysaccharide core antigens of Escherichia coli.
1986
Fenwick B.W. | Osburn B.I. | Cullor J.S. | Henry S.C. | Olander H.I.
Safety of a temperature-sensitive vaccine strain of bovine viral diarrhea virus in pregnant cows.
1986
Lobmann M. | Charlier P. | Klaassen C.L. | Zygraich N.
Vaccination of cattle against ringworm caused by Trichophyton verrucosum.
1986
Gudding R. | Naess B.
Field-trial evaluation of a Pasteurella vaccine in preconditioned and nonpreconditioned lightweight calves.
1985
Kadel W.L. | Chengappa M.M. | Herren C.E.
Immunologic response of sheep to inactivated and virulent bluetongue virus.
1985
Stott J.L. | Barber T.L. | Osburn B.I.
