Most studies on Simulum damnosum in Nigeria has focused mainly on the problem of onchocerciasis from the ecological standpoint. However, this study is aimed at viewing it from the human angle, with focus placed on the ignorance of the rural dwellers about the influences of their environment on the increasing incidences of onchocerciasis in their population. The premise is that, as the government and the scientists are working towards finding a lasting solution to the epidemic, the rural dwellers need to wake up to the realities of their own destiny. They need to come out and collaborate with other good efforts to form a strong united force that will rid their society of this menace. A study on the level of ignorance was carried out. It is assumed that their ignorance has kept the villagers relatively inactive and passive about freeing themselves. A descriptive method was used for this research and about 450 villagers were randomly selected and verbally interviewed. A questionnaire was designed and used as the instrument of the research. The research was carried out in two different villages of Asejire and Asepari. Findings were encouraging. Some of the villagers did not know about the existence of the disease even when some of their close relatives showed the symptoms. This high level of ignorance shows that it will be difficult to attain any cooperation from them in any attempt to make their environment unfavourable for the vector.