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Hepatocyte growth factor transduces different intracellular signals in aortic and umbilical venous endothelial cells
2003
Makondo, K. (Hokkaido Univ., Sapporo (Japan)) | Kimura, K. | Kitamura, T. | Yamaji, D. | Saito, M.
Endothelial cells are important for maintenance of vascular integrity by producing a variety of bioactive molecules such as nitric oxide (NO) . Recent evidence has suggested that there are some differences in characteristics between endothelial cells from different origins. Here we examined responses of two typical endothelial cells to hepatocyte growth factor (HGF), which induces endothelium-dependent relaxation of microvessels. Stimulation of human umbilical vein endothelial cells (HUVEC) and bovine aortic endothelial cells (BAEC) with HGF increased endothelial NO synthase activity, accompanied with an increase of activity-related site-specific phosphorylation of protein kinase B/Akt. However, HGF stimulated phosphorylation of p38 mitogenactivated protein kinase (MAPK) only in HUVEC, but not in BAEC, while it induced phosphorylation of p44 /p42 MAPK in both cells. These results suggest that HGF transduces different intracellular signals between aortic and umbilical venous endothelial cells, and that the differences might represent divergent endothelial responses to growth factors, especially those that activate receptor-tyrosine kinases.
显示更多 [+] 显示较少 [-]Growth pattern and seasonal weight changes of the feral raccoon (Procyon lotor) in Hokkaido, Japan
2003
Asano, M. (Hokkaido Univ., Sapporo (Japan)) | Matoba, Y. | Ikeda, T. | Suzuki, M. | Asakawa, M. | Ohtaishi, N.
In vitro infection by Ehrlichia ruminantium of baby hamster kidney (BHK), Chinese hamster ovary (CHO-K1) and Madin Darby bovine kidney (MDBK) cells
2003
Zweygarth, E. | Josemans, A.I. (Agricultural Research Council, Onderstepoort (South Africa). Onderstepoort Veterinary Inst.)
Ventriculo-atrial conduction in the ovine heart, caused by premature ventricular complexes
2003
Ker, J. (Pretoria Univ., Onderstepoort (South Africa). Physiology Dept.) | Webb, E.C.
Clinical and pathological observations on Streptococcus sp. infection on South African trout farms with gas supersaturated water supplies
2003
Huchzermeyer, K.D.A. (Sterkspruit Veterinary Clinic, Lydenburg (South Africa))
Climate change decreases habitat suitability for some tick species (Acari: Ixodidae) in South Africa
2003
Estrada-Pena, A. (Veterinary Faculty, Zaragoza (Spain). Parasitology Dept.)
Studies on the genus Setaria Viborg, 1795 in South Africa. II. Setaria scalprum (Von Linstow, 1908) and Setaria saegeri (Le Van Hoa, 1961)
2003
Watermeyer, R. | Boomker, J. (Pretoria Univ. Onderstepoort (South Africa). Veterinary Tropical Diseases Dept.) | Putteril, J.F.
Schistosoma mattheei - an ovum containing twin miracidia
2003
Van Rensburg, L.J. | Van Wyk, J.A.
Comparison of complement fixation test, immunoblotting, indirect ELISA, and competitive ELISA for detecting antibodies to Mycoplasma mycoides subspecies mycoides small colony (SC) in naturally infected cattle from the 1995 outbreak in Botswana
2003
Marobela-Raborokgwe, C. (National Veterinary Laboratory, Gaborone (Botswana)) | Nicholas, R. | Ayling, R. | Bashiruddin, J.B.
Resistance to trypanocidal drugs - suggestions from field survey on drug use in Kwale district, Kenya
2003
Mugunieri, G.L. | Murilla, G.A. (Kenya Trypanosomiasis Research Inst., Kikuyu (Kenya))
