In recent times drug repurposing has gained interest over the traditional drug discovery due to reduction in time and cost of development of new drug. Drug repurposing approach has given promising drug candidates for various viral diseases like COVID 19, Ebola, Zika, Dengue, Influenza, HIV, Herpes, etc. Ontarget and off-target are the two basic strategies of drug repurposing. Macrolide, Artemisinin, Quinoline antiparasitic drugs are some of the drugs repurposed against cancer and drugs like thalidomide are repurposed against COVID-19 infection. Repurposing of veterinary drugs like ivermectin, levamisole and benzemidazole group of antiparasitic drugs are also under consideration. This review elaborates repurposing of antihypertensive drugs like angiotensin- converting enzyme inhibitors (ACEI), angiotensin-receptor blockers (ARBs), β-blockers as anti- neoplastic drugs, anti-diabetic drugs against Alzheimer’s disease, fluorophenyl benzimidazole (FPD) as antihypertensive drug, thalidomide against COVID-19 infection, levamisole as antineoplastic drug, benzimidazole as anti-cryptococcal drug and some other new drugs. Usage of in silico techniques and pharmacophore modeling strategies can further accelerate the process of drug repurposing. The drug repurposing strategies significantly minimize research and development costs, provide greater chances of success, shorter research time and lower investment risk.

The present study was undertaken to evaluate the effect of different levels of dried capsicum powder on the quality characteristics of chicken koftas. The capsicum dried powder was incorporated at three different levels viz. 2, 4 and 6% in the formulation. The products were analyzed for various physicochemical and sensory attributes. The pH, emulsion stability (83.56±0.011) (%), cooking yield (81.12±0.011) (%), crude protein, crude fat and total ash contents of the products showed significant (P<0.05) decreasing trend with increase in levels of incorporation of dried capsicum powder. However, a significant (P<0.05) increase in the water holding capacity (%), moisture (67.10±0.008) and crude fibre (1.56±0.006) contents of the chicken koftas was observed with increasing levels of incorporation. Sensory evaluation revealed that koftas prepared with 4 per cent capsicum dried powder had superior scores (P<0.05) compared to 2 and 6 per cent. Hence, incorporation of dried capsicum powder at 4 per cent level in chicken koftas was considered to be optimum. (Include some values of important findings). 

An one and half year old Jersey crossbred heifer was presented to the Veterinary Clinical Complex, Veterinary College and Research Institute, Namakkal with the history of recurrent bloat, copious salivation, severe respiratory distress and abdominal distension. Under local infiltration with 2% lignocaine hydrochloride, trocharization was performed on left paralumbar fossa using trochar and canula to relieve the gas from the rumen. Palpable hard mass noticed in the caudal cervical esophagus and attempt was made to retrieve with the hand through the oral cavity was unsuccessful. Oesophagogram revealed barium stasis on ventral aspect between 4 th and 5 th cervical vertebra. As the obstruction could not be relieved by passing a probang, cervical oesophagotomy was performed and foreign body (Trichobezoar) was retrieved without any complications.

Contamination of locally fermented cow milk (Nono) by pathogenic bacteria constitute a major public health problem. This was because contaminated milk was a good medium that can support the growth and propagation of microbial pathogens. This study was designed to assess the bacteriological quality of locally fermented cow milk consumed in Maiduguri, northeastern Nigeria. Totally, forty (n = 40) samples of fresh, locally fermented cow milk (Nono) were collected and used in this study. Ten (10) milk samples each were collected from four randomly selected selling points (Monday Market, Custom Market, Kasuwan Shanu and Tashan Bama). The bacteriological quality of each milk sample were analysed using standard procedures for isolation, identification and enumeration of pathogenic bacteria. The mean total plate count ranged from 1.44x10 8 CFU/mL to 10.31x10 8 CFU/mL, while the mean total coliform count range from 0.57x10 8 CFU/mL to 11.17x10 8 CFU/mL. Statistically, there was a significant difference (p<0.05) in the mean total plate count and coliform count of milk samples collected from the four sampling points.Bacteriological culture and biochemical identification of all the isolates revealed Escherichia coli29(72.5%), Klebsiella specie3(7.5%), Salmonella specie 2(5%), Staphylococcus aureus 14(35%) and Streptococcus specie15(37.5%) respectively. All the results were above the acceptable limits (1.0 to 3.0 x 10 5 CFU/mL for total plate count and no coliform count per 100ml of milk sample) set by NAFDAC. Therefore the Nono products consumed in Maiduguri was not safe and wholesome for public consumption. Hence, the need to ensure the maintenance of standard hygienic protocols during the collection, storage, processing and marketing of locally fermented cow milk (Nono) in order to minimize microbial contamination.

A biological trial was conducted to study the effect of multi enzyme supplementation on ileal digestibilities of dry matter (DM), crude protein (CP), ether extract (EE), phytate phosphorus (PP) and non-starch polysaccharides (NSPs) in terms of neutral detergent fibre (NDF), acid detergent fibre (ADF), hemicellulose and cellulose in broilers for a period of 0-6weeks. The broilers used in this trial were fed diets supplemented with enzyme at 0, 250, 500, 750 and 1000 g/ton of feed with a proportionate reduction in metabolizable energy (ME-1.25, 2.5, 3.75 and 5 %), crude protein (CP-0.75, 1.5, 2.25 and 3 %), methionine + cytine (0.5, 1, 1.5 and 2 %) and available phosphorus (2.2, 4.4, 6.6 and 8.8 %). The level of individual enzyme per gram of multi enzyme supplement was cellulase 146 IU, xylanase 241 IU, pectinase 98 IU, protease 74 IU, amylase 778 IU and phytase 33 IU. The ileal digestibility was conducted on 6 th week of trial. The ileal DM digestibility (%) was significantly (p<0.01) increased in 750 g and 1000 g enzyme supplemented groups than other treatment groups. The increase in ileal DM digestibility was significantly (p<0.01) higher (6.2 %) in the group fed with 750 g enzyme supplementation than control. The digestibility of ileal crude protein (%) significantly (p<0.01) increased in 500, 750 and 1000 g enzyme supplemented groups than control. The increase in ileal protein digestibility was 12.20 % in 500 g/ton, 9.90 % in 750 g/ton and 10.12 % in 1000 g enzyme supplemented groups than control. However a non significant difference was observed in ileal EE digestibility in all treatment groups. The ileal phytate phosphorus digestibility significantly (p<0.01) increased in all the enzyme supplemented groups (33.69 % in 250 g/ton, 38.75 % in 500 g/ton, 39.53% in 750 g/ton and 42.11% in1000 g/ton) than control (31.71%). A highly significant (P< 0.01) increase in ileal neutral detergent fibre (NDF) and hemicellulose was observed in 500 to 1000 g enzyme supplemented groups than control. Similarly significant (P<0.01) increase in ileal acid detergent fibre (ADF) and cellulose digestabilities (%) were observed in all enzyme supplemented groups than control. It was concluded that the multi enzyme supplementation at minimum inclusion level of 500 g per ton of feed increased the ileal digestibilities of CP, PP, NDF, ADF, hemicelluloses and cellulose by 12.20 %, 18.17 %, 13.57 %, 55.63 % 12.77 % and 52.64 % respectively than control in broiler diet than the control diet in broilers.

The aim of this study was to evaluate two different superovulation protocols for quality embryo production. Donor animals were selected (Day 0) and a progesterone device was inserted. The superstimulatory treatment was initiated in day 7 (D7) with follicle stimulating hormone from porcine (FSHp) in eight decreasing doses each at 12 hours interval. Along with the fifth dose of FSHp, 500μg cloprostenol was administered. The progesterone device was removed 12h (Treatments P12) and 24 h after the first application of cloprostenol (Treatments P24). Twelve hours after the eighth dose of FSHp (D11) 25µg of Buserelin was administered and the inseminations were done after 12 and 24 hours. Embryos were collected in the forenoon of D18. P24 presented better results than the P12 treatment.

One hundred lambs (11.8 kg ± 0.56) divided at random into 4 groups G1, G2, G3 and G4 were supplemented with exogenous fibrolytic enzyme mixture (EFE) in concentrates after 6 hours outside grazing. G1 and G2 were given 200 and 400 g of EFE per 50 kg feed in dry form, G3 and G4 were given EFE in solubulized form at 20 and 40 g per litre of water, respectively. The initial and final weights (kg) were non-significant among treatments. The total weight gain (kg) was higher (P<0.05) for G4 and G2 as compared to other two. Average daily gain (g) was highest (P<0.05) for G4 followed by G2, G1 and G3. Total weight gain (%) is 15, 7.6 and 16.5 lower (P<0.05) for G1, G2 and G3 (Table) as compared to G4. Lowest (P<0.05) FCR was observed for G4 and is in the order of G4< G2< G1< G3. The cost of the feed per kg gain was lower (P<0.05) by 21%, 26% and 13% for G4 as compared to G1, G2 and G3. It can be concluded that addition of EFE in solubulized form was found better for the reason that it forms a stable complex with the feed and thus facilitates for the rumen bacterial attachment earlier for rapid action due to an increase in rumen bacterial population

Ceftizoxime is the third generation cephalosporin, extensively used in veterinary medicine. It has larger volume of distribution, good penetration into tissues, and useful for the treatment of mastitis which is resistant to other antibiotics. Keeping in view of generating pharmacokinetic data of ceftizoxime in different domestic animals, the present study was planned to investigate pharmacokinetics of ceftizoxime in goats (n = 6) at the dose rate of 10mg kg-1 body weight following single dose intravenous administration. Drug concentration in plasma was determined using High Performance Liquid Chromatography (HPLC) with UV detector. The values of Cmax, AUC and MRT were 44.40 ± 2.09 µg ml-1, 121.22 ± 15.40µg.h.ml-1 and 11.44 ± 1.30 h, respectively. The longer elimination half-life (8.92 ± 1.11h) along with smaller ClB (0.09 ± 0.01 Lh-1 kg-1) showed slower excretion of the drug from animal body. 

A survey was conducted among the small holder dairy farmers in 80 Panchayaths of 14 districts in Kerala in order to evaluate the reproductive performance of crossbred cattle population in Kerala at field level. Analysis of the data showed that the herd size of cattle in Kerala was around 3 per house during the period of 2012 and 2013. Three fertility traits, age at first calving (AFC), calving interval (CI) and number of services per conception (NSC) were studied in detail and the averages of these traits were 1093 ± 10.52 days, 551 ± 48 days and 2.02 ± 0.01 services per conception, respectively. Fixed model analysis was carried out to see the effect of some of the major factors leading to variation in AFC, CI and NSC and found that there was significant difference in reproductive performances among different genetic groups. AFC and NSC of crossbred Holstein Friesian cows and CI of Sunandini cows were lower compared to other genetic groups. Other factors significantly influencing AFC were period of birth and season of birth. Apart from genetic groups, number of services per conception was influenced by type of semen used and also the level of peak milk production.

The present study was undertaken to induce gonadal maturation of Mrigal, Cirrhinus mrigala using Human Chorionic Gonadotropin (HCG) implants in captive conditions. The male and female fishes of C. mrigala were implanted intramuscularly with hCG implants at the dosage of 1000 IU/kg body weight, to study the effect of hCG hormone. Hormone implants were given once in two months during the experimental period of February to June. Histological observation in the ovary of C. mrigala revealed the presence of four types of growing oocytes namely perinucleolar, previtellogenic, vitellogenic and hydrated oocytes. Histological observation of the testis of C. mrigala showed the presence of five types of spermatogenic cell types namely spermatogonia, primary spermatocytes, secondary spermatocytes, spermatids and spermatozoa. Hence, the present study recommends that hCG implants can successfully be used to induce sustained maturation of C. mrigala in captivity even during off season.