In recent times drug repurposing has gained interest over the traditional drug discovery due to reduction in time and cost of development of new drug. Drug repurposing approach has given promising drug candidates for various viral diseases like COVID 19, Ebola, Zika, Dengue, Influenza, HIV, Herpes, etc. Ontarget and off-target are the two basic strategies of drug repurposing. Macrolide, Artemisinin, Quinoline antiparasitic drugs are some of the drugs repurposed against cancer and drugs like thalidomide are repurposed against COVID-19 infection. Repurposing of veterinary drugs like ivermectin, levamisole and benzemidazole group of antiparasitic drugs are also under consideration. This review elaborates repurposing of antihypertensive drugs like angiotensin- converting enzyme inhibitors (ACEI), angiotensin-receptor blockers (ARBs), β-blockers as anti- neoplastic drugs, anti-diabetic drugs against Alzheimer’s disease, fluorophenyl benzimidazole (FPD) as antihypertensive drug, thalidomide against COVID-19 infection, levamisole as antineoplastic drug, benzimidazole as anti-cryptococcal drug and some other new drugs. Usage of in silico techniques and pharmacophore modeling strategies can further accelerate the process of drug repurposing. The drug repurposing strategies significantly minimize research and development costs, provide greater chances of success, shorter research time and lower investment risk.

A study was carried out to check the prevalence of Salmonella spp. in ice cream marketed in Thrissur city, Kerala. Altogether 80 ice cream samples belonging to 10 different brands were randomly collected from different retail outlets of the city and were analysed for total viable count, coliform count and for the presence of Salmonella spp. The mean total viable count and coliform count in ice cream samples were 11.90±0.06 and 3.72±0.17 log cfu/g respectively. Thirty per cent of the ice cream samples exceeded the standards prescribed for coliform count by Food Safety and Standards Act (2006). Salmonella spp. was isolated from one of the ice cream samples. The presence of potential pathogen such as Salmonella in ice cream samples reveals the importance of strengthening the quality control measures to be followed during manufacture as well as storage and distribution of ice cream in order to reduce public health risk.

The morphology of the abducent nucleus of the buffalo has been described by materials collected from eight buffalos. Nissl and myelin stained serial and semi serial sections of brain stem were used for the study. The abducent nucleus in the buffalo extended from the cranial pole of the rostral cochlear nucleus to the caudal pole of the motor nucleus of the trigeminal nerve. An accessory abducent nucleus which is present in amphibians, reptiles, birds and some mammals could not be identified in the buffalo. The nucleus appeared as a rounded body in its caudal pole and was roughly triangular at rostral pole in transverse sections. The average length of motor nucleus of abducent nerve in the buffalo was 2.4 mm. The average maximum width and height of the nucleus was 1.48mm and 1.75 mm respectively.

An attempt was made to document the management practices of the backyard goat production in Cauvery Delta zone of Tamil Nadu. The primary data were collected by interviewing 180 backyard goat farmers selected by multi-stage random sampling using pre-tested interview schedule and analyzed through descriptive statistics. About 46.11 per cent of the respondents kept their animals under open system of housing and floor of the goat shed was mud type in 96.67 per cent of the sampled farmers. All the farmers stored manure in an open place. Majority of goat farmers raise their goats solely on browsing and grazing stubble of field crops, natural pasture and tree leaves. Majority of farmers did not possess their own breeding buck but they use community buck for breeding purpose. Middlemen (57.22 per cent) played a major role in marketing of goat in all categories of flocks, followed by butcher (36.11 per cent). Only one-fifth of flock owners dewormed their flocks yearly twice. None of the sample respondents vaccinated their goat against infectious diseases. Goats were marketed round the year (87.78 per cent) and about 12 per cent marketed their goats on special occasions. The major reasons for marketing was found to be the want of money to overcome financial problem (61.07 mean score) in case of bucks / male kids and culling due to old age (66.00 mean score) in case of breeding does. Majority of the sample backyard goat farmers did not follow scientific  management practices at their farm level, which warrants intensive extension programmes. Implementation of best management practices among backyard goat farmers in Cauvery Delta zone of Tamil Nadu would improve the profitability.

An one and half year old Jersey crossbred heifer was presented to the Veterinary Clinical Complex, Veterinary College and Research Institute, Namakkal with the history of recurrent bloat, copious salivation, severe respiratory distress and abdominal distension. Under local infiltration with 2% lignocaine hydrochloride, trocharization was performed on left paralumbar fossa using trochar and canula to relieve the gas from the rumen. Palpable hard mass noticed in the caudal cervical esophagus and attempt was made to retrieve with the hand through the oral cavity was unsuccessful. Oesophagogram revealed barium stasis on ventral aspect between 4 th and 5 th cervical vertebra. As the obstruction could not be relieved by passing a probang, cervical oesophagotomy was performed and foreign body (Trichobezoar) was retrieved without any complications.

The identification and development of new and effective alternatives to antibiotics that do not hinder productivity assumes paramount importance in the context of antimicrobial resistance and food safety. In recent years, phytobiotics have been used as natural growth promoters in ruminants, poultry and swine, to improve growth and health. A wide variety of herbs, spices and essential oils have been used individually or as blends in poultry for their potential application as alternative growth promoters. In nursery and growing pigs supplemented with phytobiotics, intestinal pathogens were inhibited and beneficial microbial population that contributes to improving digestion and absorption of nutrients were increased resulting in increased weight gain and decrease in diarrheal syndrome. The inclusion of essential oils in the diet of finishing pigs, improved the productive yield and carcass characteristics. It also reduced the incidence of therapeutic treatment and mortality. Natural plant products have the potential to improve rumen fermentation, reduce loss of feed energy, improve animal health and productivity, increase animal lifetime performance, and reduce greenhouse gases production in ruminants. Phytobiotics with wide range of activities, is projected as a feed additive for higher market growth compared to other alternatives to antibiotics in the feed industry.

A total of 203 blood samples were collected along with data on age at first calving from Murrah / graded Murrah buffaloes maintained at different organized farms. Genomic DNA isolation and Polymerase Chain Reaction (PCR) were performed to amplify the PCR products and were digested with HpaI restriction enzymes overnight. Population genetic indices was calculated based on basic statistical tools. At the MTNR1A / HpaI locus, three genotypes viz., CC, CT and TT identified, with frequencies of 0.225, 0.505 and 0.270 respectively. The allele frequencies of C and T alleles were 0.478 and 0.522 respectively. The overall means of age at first calving was 1385.76 ± 24.31 days. Individuals with the CT and TT genotypes (1356.78 ± 33.03 and 1378.38 ± 37.66 days) had shorter age at first calving than CC genotype (1422.14 ± 53.01 days) and the differences were statistically significant (P<0.05).

A study was conducted to evaluate the biomass yield and proximate composition of biomass from the natural pastures of Madras Red sheep. Eight villages were selected from the habitat of Madras Red sheep and 40 samples each during  rainy and summer season were collected to assess the biomass yield and proximate composition. The study showed that biomass yield and proximate composition were higher during the rainy season during which these sheep completed their breeding, reproduction and lactation. The total dry matter content was higher during the summer season which was able to meet maintenance requirement of sheep during these months. Farmers managed these animals without any supplementary feeding, but during summer the animals were let in the harvested fields where they had access to crop residues for grazing.

In the present study, the expression pattern of OAS-1 and MX-2 gene in peripheral blood mononuclear cells (PBMC) was associated with the early pregnancy in cattle. A total of 60 animals were selected and divided into 2 groups, treatment (50) and control (10) group and synchronized using double PGF2α protocol by 11 days apart followed by insemination at 72 and 96 hrs after second dose of PGF2α. The cows were subjected to blood collection on day 0, 14, 18, 20 and 25 post insemination and Peripheral Blood Mononuclear Cells (PBMC) were harvested using Histopaque® solution, followed by RNA isolation and cDNA synthesis. A significantly (P≤0.01) higher expression of OAS-1 and MX-2 gene was observed on days 18 and 20 post oestrum by quantitative real-time PCR and concentration of MX-2 protein in serum were significantly higher (P≤0.05) on day 18, 20 and 25 in pregnant cows when compared with that of non-pregnant cows. Hence, the present study is concluded that the expression of OAS-1 and MX-2 genes and their encoded proteins may be used to develop a marker for early pregnancy diagnosis in cattle.

A proper care, prompt reporting and immediate surgical inervention will save the life of the animal. A four year old pluriparous doe was presented with the history of dog bitten wound with eviscerated mass from the injured site at the left lateral aspect of the abdomen. The goat was kept on lateral recumbancy, on clinical examination revealed eviscerated rumen without any lacerations. Surgical area was prepared aseptically, under Inj. Xylazine as premedication and Inj. ketamine and inj. diazepam as induction anaesthesia reconstructive surgery was performed. Rumenotomy was performed to reduce the content and rumen was closed by the two rows of inversion suture. Peritoneum and transverse abdominus muscle were apposed by inversion suture pattern and oblique abdominus internus and externus muscle were apposed by interrupted suture pattern using catgut no 1. Skin was apposed by interupted suture pattern using cotton thread (no 8). Postoperatively Inj. Tetanus toxoid (5 Lfu), ceftriaxone @ 10 mg per kg and meloxicam @ 0.5 mg per kg were given intramuscularly and the animal was maintained with fluid therapy, antibiotic and analgesic for five days and animal recovered after one week.