About 8 year-old castrated male Yorkshire terrier was presented for evaluation of dysuria, stranguria, hemtauria, and pollakiuria. On history taking, dysuria first was observed three months ago and these signs were waxed and waned. Physical examination revealed mild left perineal swelling. On routine laboratory examination, no significant findings were identified. Positive contrast urogram identified peritoneal herniation of urinary bladder. Urinalysis showed proteinuria and hematuria.

We established an in vitro experimental system using the following procedure. We first introduced tritium-labeled norepinephrine ([³H]-NE) into PC12 cells. The [³H]-NE incorporated into PC12 cells were then stimulated by a high concentration (60 mM) of K+ buffer during 12 minutes. Then, we collected 100 μl supernatant and counted the amount of [³H]-NE release from PC12 cells with a scintillation counter. After screening fungal, Streptomyces spp. or bacterial product using this experimental sytem, we obtained FS11052 from Streptomyces spp. which inhibited [³H]-NE release from PC12 cells.

All-trans retinoic acid (AtRA) induces growth inhibition and apoptosis in a variety of tumer cells, including MCF-7 cells. Insulin-like growth factors (IGFs) system has been reported to be associated with the development of cancer. Although MCF-7 cell with AtRA is to be the major stimulus for the cell growth and apoptosis, the mechanism of insulin-like growth factor-I (IGF-I)/insulin-like growth factor binding protein-3 (IGFBP-3) system remains to be elucidated. Thus, this study was conducted to the effect of AtRA on the gene expression and level of IGF-I and IGFBP-3.

Pasteurella multocida is a terrible veterinary pathogen that causes widespread infections in husbandry. To induce homologous and/or heterologous immunity against the infections, outer membrane protein Hs (OmpH) in the envelope of different strains of P. multocida are thought to be attractive vaccine candidates. Previously we cloned and characterized a gene for OmpH from pathogenic P. multocida (A:3) (In Press, Korean J. Microbiol. Biotechnol. 2005, 33, December).

Shiga toxin (stx) producing Escherichia coli (STEC) causes various clinical signs in animal and himan. In this study, 255 fecal samples from samples from calves showing diarrhea were collected from cattle farms in Chonnam province during the period from January 2005 to July 2005. Twenty six STEC (10%) were isolated from 255 fecal samples by PCR. The isolates displayed three different stx combinations (stx1[69%], stx1 and stx2 [15%], and stx2 [38%]). The isolates were further studied for virulence associated genes and antimicrobial resistance to define the virulence properties.

A stochastic simulation model incorporated with Reed-Frost approach was derived for evaluating diagnostic performance of a test used for a screening program of an infectious disease. The Reed-Frost model was used to characterize the within-herd spread of the disease using a hypothetical example. Specifically, simulation model was aimed to estimate the number infected animals in an infected herd, in which imperfect serologic tests are performed on samples taken from herds and to illustrate better interpreting survey results at herd-level when uncertainty inevitably exists.

A 6-year-old female Jindo dog weighing 20 kg was presented to the Veterinary Medical Teaching Hospital of Seoul National University for the formation of crust and erosion of the nasal bridge and planum, and for alopecia of ear margin. Erythema, crusts, alopecia and erosions were present in the nasal planum and the bridge of the nose on physical examination. There were no abnormalities on CBC, serum chemistry, and basic dermatologic examination which included skin scraping, bacterial cultures, and fungal cultures.

This study was conducted to investigate the effect of aqueous extract of Mentha longifolia supplemented to broilers on some physiological parameters represented by hematological characteristics . A total of 90 chick of broiler faobre strain from IPA center for agricultural researches were used at one day old . The birds at 4th day old , were randomly assigned into three groups . Each group consisted of thirty birds . The control groub ( c ) was not treated , T1 group treated with aqueous extract 1 ml / day of concentration 0.25 (gm / ml water) and T2 group was treated with aqueous extract 1 ml / day of 0.125 gm/ml concentration and for eight weeks . All groups were fed the same commercial basal ration of broiler and the same environmental condition and vaccinations were allowed to each group . The results of blood samples tests were as follows . Treated birds expressed high values of blood hemoglobin concentration and packed cell volume percentage and showed significant difference ( p < 0.05 ) compared with control group . The birds ofT1 group indicated high significant increased( p < 0.05 ) in total leukocytic count compared V with the T2 & control group . Theres is , significant increased ( p< 0.05 ) in numbers V of TWBCS in T2 group compared with a control group . A total erythrocytic counts revealed that there were Significant differences ( p < 0.05 ) between groupsln numbers of Red blood cells by increasing the number of red blood cells in treated group . These results refered to the benefit of aqueous extract of Men!/m /ongifolia to broiler chicken at concentrations of 0.25 and 0.125 gm /ml

The present study is an attempt to determine the Etiology (Bacterial & Parasitic) of Buffaloes Pulmonary Lesions. For this purpose samples of(105) affected lungs were collected ’ "from abattoirs. of the cities in southern part of Iraq named (Basra, Amara, Nassirya and the Qurna). * 1 Samples of the investigation were obtained through the examination of a total of (917) lung apparently healthy buffaloes examined in six months period from 1st of October 1980 to end ofMarch 1990. Among the encountered Pulmonary Lesions, (68) = eases ((>4.7(>%) were associated with bacterial isolation and from (6) cases (5.71%) no etiology identified. The various bacterial isolates associate with different pulmonary lesions are mentioned and it's significance is discussed. Pulmonary parasitic infection were encountered in (31) cases « (29.5%) of all types of lung affection observed among which one case (3.2%) was caused by V Dict. viviparous and one case of migration of liver flakes (Fasciola gigantic) twenty nine (93.2%) due to larval ofthe tape worm (echinococcus granulose ).

A total of 531 serum samples were subjected to Rose Bengal test (RBT) , serum agglutination test (SAT) and indirect flurocent antibody test (IFAT) and ELISA. The incidence of brucellosis was found to be 55.76%, 47.64% ,55.76% , and 58.70% ,on basis ofRBT.SAT.lFATand ELISA respectively . The agreement between the RBT and . SAT was 85.47% and between RBT and IFAT was 100% ingiving apositive result. lncase of ELISA the positive results was higher and we recommended using it as the defenitive test for detection of brucellosis