In order to clarify the pathogenesis of perirenal edema, pigs and rabbits were administered with oxalate and nitrate, with oxalate nitrate and glycolic acid, with oxalate, nitrate and ascorbic acid and with oxalate, nitrate and calcium, respectively. The pigs and rabbits administered with oxalate and nitrate with oxalate, nitrate and glycolic acid and with oxalate, nitrate and ascorbic acid, respectively, were not showed perirenal edema despite of observing the abundant oxalate crystals in the proximal convoluted tubles

This paper deals with the isolation of Salmonella on 3 herds during the period from May 1984 to May 1985. Isolated Salmonella were examined for serotypes, adhesive fimbriae, antibiotic susceptibility and detection of R plasmid. Of total 1505 cattle, 24 Salmonella were isolated from 18 cattle (1.2%) and their serotypes were S. enteritidis (9 strains), S. derby (4 strains), S. infantis (1 strain), C1 group (8 strains), C2 group (1 strain) and untypable (1 strain). Twelve strains of Salmonella were isolated from 227 cattle with diarrhea and their serotypes were S. enteritidis (4 strains), S. derby (3 strains), S. infantis (1 strain), C1 group (3 strains) and untypable (1 strain)

The prevalence of antibody to Getah virus was serologically followed among those horses in Korea. Blood samples were taken from 575 horses in Feb and 462 horses in Sep. 1985. Overall percentage of horses with seropositive to Getah virus was 37% in Feb and 47% in Sep. The data suggest that the Getah virus infection was endemic in Korea and the increase in prevalence may be associated with the seasonal activity of arthropod vectors. This entails preventive precautions of the horses against this viral infection before the entry into Korea

Microcarrier culture technics were widely used for the massive production of the vertebrate animal cells. In this study, attempt was made to establish the microcarrier cell culture system using Cytodex. Various factors affecting the growth of cells on microcarrier culture were also discussed. In conclusion, the yield of cells in microcarrier culture was several times greater than those in roller bottle and flask culture methods, based on the volume of culture media

Sprague-Dawley rats received subcutaneous injections of gentamicin sulfate, 50 and 100mg/kg for 3, 7 and 10 days. The hematological and blood chemical values were determined. Kidneys were examined histologically and ultrastructurally. The serum values of aspartate transaminase, blood urea nitrogen and creatinine in the rats administered gentamicin, 50 and 100mg/kg/day were significantly increased than those in the control. The ratio of kidney weight to body weight was significantly increased in the rats injected gentamicin, 100mg/kg for 10 days than those in the control

In order to know the comparative histological structure of the tongue of some domestic and laboratory animals, the root of the tongue has been investigated by light microscopy. The filiform papillae were mainly distributed in the root of the tongue of most animals and many foliate papillae were also found in the dog and rabbit. The very well-developed mucosa was found in the cattle and in the dog, fowl, rat and mouse was fair. The lamina propria was well developed in the cattle, dog and pig. The muscle layer was well developed in the cattle. The adipose tissue which distributed between the muscle fibers was mainly found in the dog

In order to evaluate the effects of the cell-mediated immunity of the animal in the chronic diseases the guinea pigs and rabbits were inoculated with Mycobacterium bovis. After 6 weeks these animals were sensitized and challenged with 2, 4-dinitrochlorobenzene. The cutaneous reactions observed in these animal species were similar each other. Macroscopic and microscopic responses in the animal experimentally infected with M. bovis were markedly reduced compared to those in the control animals

The present study was carried out to observe the histopathological changes in the lung of A/J, C57BL/6N, DBA/2 and NIH-GP mice intratracheally instillated with benzo(a)pyrene or urethan. In the group of intratracheal instillation with benzo(a)pyrene and charoal powder, squamous cell carcinomas and adenocarcinomas were induced. Tumors were induced in high incidence in the lung of A/J and C57BL/6N mice. Especially, squamous cell carcinomas were induced in high incidence and were well-differentiated in the lung of A/J mice

The present study was undertaken to investigate the development of early embryos, the implantation rate in immature rats superovulated by transplantation of a pituitary gland. Thirty-day-old male rats were performed orchidectomy 15 days before removal of each pituitary orchidectomy 15 days before removal of each pituitary gland. A pituitary gland was transplanted under the right kidney capsule of 28-day-old female rat between 0700 and 1000h on the starting day of experiment which was designated as Day -2. Control rats were administered 4 IU PMSG at 1000 on day -2. Some of rats used to experiment were sacrificed to examine the changes of ovarian and uterine weights on days -2, -1, 0, 1, 2, 3 and 5. Other rats were sacrificed to recover the ova and observe the ovaries on Days 1, 2, 3 and 5. The implantation sites were counted on Days 8