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Brucella chemotherapy i. studies of the effect of para aminobenzoic acid on brucella in vitro
1948
Cotton, C.M. | Swope, R.C.
1. Tests in vitro were made with 2 strains each of Brucella abortus, Br. suis and Br. melitensis. On tryptose agar, 2 mg. per ml. of P-aminobenzoic acid or 5 mg. per ml. of Na p-aminobenzoate completely inhibited growth in all strains. Organisms suspended in distilled water were killed by all concentrations from 3 to 20 mg. per ml., and Na p-aminobenzoate was the more effective inhibitor in all dilutions. Br. abortus was the most resistant organism. In tryptose broth, concentrations below 6 mg. per ml. did not produce sterility. In a medium containing blood the Na salt was more effective than the acid.
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