Purpose. To define the role of fertilizers containing amino acids in the nutrition systems of highly productive varieties of winter wheat. Methods. Field studies, biochemical technique, analytical procedure, statistical evalua­tion. Results. In the process of investigations, sufficiently high activity of fertilizers containing amino acids was established when applying them for leaf-feeding. Fertilizers based on algae (Megafol, Megafol Protein, Terra-Sorb foliar) and animal (Izabion) hydrolysates appeared to be very effective for increasing yield of culture. It was found that in case of low doses of mineral nitrogen, fertilizers helped to increase both the yield and quality indicators of high-yielding wheat variety. Conclusions. It was defined that fertilizers that include amino acids are highly effective compositions containing plant-available nitrogen in organic form and can be promising for application as antistress agents and improving efficiency of macro- and microelements use by cultivated plants. They are essential components of modern technologies for cultivation of highly productive varieties and hybrids in crop production of Ukraine.