Urban morphology impacts micro-climates, solar energy absorption, air flow, wind patterns, energy consumption, and air pollution concentration. Temperature control in public spaces reduces heat island formation, while ventilation corridors potentially improve air quality. However, despite the literature on airflow and urban tall buildings providing valuable insights, further research is needed to understand the complex relationship between airflow patterns and urban high-rise buildings. This research should consider factors such as landscape types, building height, density, and orientation. This research aims to examine airflow patterns in high-rise buildings that are influenced by nearby land use, which can impact ventilation and climate comfort. To investigate these objectives, we utilized the Universal Thermal Climate Index (UTCI) and Predicted Mean Vote Index (PMV) by conducting simulations using ENVI-met software. The results revealed that buildings with narrower widths have better wind warded front conditions, while those with an unfavorable wind angle or a narrow facade are less comfortable. Public spaces that face the wind benefit from improved ventilation. It is essential to consider the optimal arrangement, ventilation, and height of buildings to ensure the favorable airflow. Factors such as the placement of trees, the use of porous walls, water features such as fountains and sprinklers, and the local climate all contribute to creating better wind conditions. Investigating the reciprocal interaction between the landscape, high-rise buildings, and climate comfort could be considered in future research.