Heavy metals that enter marine environment and remain in the water as well as the sediments are accumulated by aquatic organisms, thus becoming highly good indicators to monitor metal accumulation in the long run. Metals are potentially harmful to humans and most organisms at varied levels of exposure and absorption. Northern East Mediterranean Sea is a crucial region as it is an area, shared by numerous aquatic species with pollutant factors such as heavy marine traffic, transportation ports, industry plants, iron and steel works, oil pipeline installation, and other small factories. While the previous part of this review (Review of heavy metal accumulation on aquatic environment in Northern East Mediterranean Sea part I: some essential metals) evaluated the data from previous studies concerning toxic effects of selected essential metals on seawater, sediment, and different tissues of aquatic animals, collected from different areas in Northern East Mediterrenean Sea since the 1990s, the present part intends to evaluate the data from previous studies on toxic effects of selected non-essential metals. For this purpose, 94 articles and 6 theses have been examined and a good deal of information has been gathered to open a forward-looking view of the studied area’s pollution. Althought there has not been any harmonization, when comparing heavy metals investigations in the bay, all studies have shown that consumption of aquatic species from the region causes no problem to human health.

Coronavirus (COVID-19) pandemic ushered in a new era that led to the adjustments of diverse ecosystems. The pandemic restructured the global socio-economic events which prompted several adaptation measures as a response mechanism to cushion the negative impact of the disease pandemic. Critical health safety actions were imperative to curtail the spread of the disease such as wearing personal protective equipment (PPEs), masks, goggles, and using sanitizers for disinfection purposes. The daily demands for the products by individuals and medical personnel heightened their production and consumption, leading to a corresponding increase of COVID-19 wastes in the environment following indiscriminate waste disposal and poor waste management. The persistent occurrence of COVID-19 wastes aggravated microplastics (MPs) contamination in the aquatic ecosystem following the breakdown of PPEs-based plastics via oxidation, fragmentation, and photo-degradation actions. These MPs are transported in the aquatic environment via surface runoff and wind action, apart from discrete sources. MPs' presence in the aquatic systems is not without repercussions. Ingestion of MPs by aquatic organisms can cause several diseases (e.g., poor growth, oxidative distress, neurotoxicity, developmental toxicity, reproductive toxicity, immunotoxicity, and organ toxicity). Humans are at high risk of MPs uptake. Apart from aerial and soil contamination sources, consumption of aquatic food products is a critical pathway of MPs into the human body. MP toxicities in humans include liver disorder, respiratory failure, infertility, hormonal imbalance, diarrhea, developmental disorder, and mortality. Measures to alleviate the effect of COVID-19 waste litters include effective waste management plans and the adoption of technologies to extract cum degrade MPs from the aquatic and terrestrial environment.