Tropospheric ozone is the most important single air pollutant of importance to forests in eastern United States. Both broadleaf and needled trees may suffer premature foliar senescence following even low ozone exposure years. Genetic sensitivity within species is likewise prevalent.

Air pollutants cause subtle changes in natural resistance that can prediscope plants to insect attack. The majority of reports in the area of plant-pollutant-insect interactions have been correlative in nature. In the last ten years, there has emerged a growing body of literature, the vast majority with herbaceous crops, reporting on cause-effect relationships among insects and their hosts.

Air pollutants such as ozone may affect tree host-pathogen interactions by altering plant tissue susceptibility, plant resistance, pathogen virulence and inoculum density. Ozone has been shown to weaken trees in natural stands and increase their susceptibility to invasion by plant pathogens, such as Heterobasidion annosum. Ozone has also been shown to enhance disease development by fungi that are normally saprophytic in nature.

Calcium avaiability to forests has been shown to be reduced by acidic deposition in several ways including: increased leaching from foliage, increased leaching from soils, and decreased availability from poorly buffered soils when aluminium is mobilized. Studies documented that acidic deposition has altered the growth and vigour of red spruce during the past three decades by changing calcium availability.

Experimental research on the physiology of tree seedlings under simulated climate and doubled carbon dioxide can rarely be extrapolated to grown forests. Climatological research has demonstrated a warming trend in the north and a cooling trend in the south of China. However, the changing climate has not caused the death of forests. Projecting the impact of climate change on forest distribution and growth using current GCMs seems to be the only method available.