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Decrease in life expectancy due to COVID-19 disease not offset by reduced environmental impacts associated with lockdowns in Italy 全文
2022
Rugani, Benedetto | Conticini, Edoardo | Frediani, Bruno | Caro, Dario
The consequence of the lockdowns implemented to address the COVID-19 pandemic on human health damage due to air pollution and other environmental issues must be better understood. This paper analyses the effect of reducing energy demand on the evolution of environmental impacts during the occurrence of 2020-lockdown periods in Italy, with a specific focus on life expectancy. An energy metabolism analysis is conducted based on the life cycle assessment (LCA) of all monthly energy consumptions, by sector, category and province area in Italy between January 2015 to December 2020. Results show a general decrease (by ∼5% on average) of the LCA midpoint impact categories (global warming, stratospheric ozone depletion, fine particulate matter formation, etc.) over the entire year 2020 when compared to past years. These avoided impacts, mainly due to reductions in fossil energy consumptions, are meaningful during the first lockdown phase between March and May 2020 (by ∼21% on average). Regarding the LCA endpoint damage on human health, ∼66 Disability Adjusted Life Years (DALYs) per 100,000 inhabitants are estimated to be saved. The analysis shows that the magnitude of the officially recorded casualties is substantially larger than the estimated gains in human lives due to the environmental impact reductions. Future research could therefore investigate the complex cause-effect relationships between the deaths occurred in 2020 imputed to COVID-19 disease and co-factors other than the SARS-CoV-2 virus.
显示更多 [+] 显示较少 [-]Polystyrene microbeads influence lipid storage distribution in C. elegans as revealed by coherent anti-Stokes Raman scattering (CARS) microscopy 全文
2022
Fueser, Hendrik | Pilger, Christian | Kong, Cihang | Huser, Thomas | Traunspurger, W. (Walter)
The exposure of Caenorhabditis elegans to polystyrene (PS) beads of a wide range of sizes impedes feeding, by reducing food consumption, and has been linked to inhibitory effects on the reproductive capacity of this nematode, as determined in standardized toxicity tests. Lipid storage provides energy for longevity, growth, and reproduction and may influence the organismal response to stress, including the food deprivation resulting from microplastics exposure. However, the effects of microplastics on energy storage have not been investigated in detail. In this study, C. elegans was exposed to ingestible sizes of PS beads in a standardized toxicity test (96 h) and in a multigeneration test (∼21 days), after which lipid storage was quantitatively analyzed in individual adults using coherent anti-Stokes Raman scattering (CARS) microscopy. The results showed that lipid storage distribution in C. elegans was altered when worms were exposed to microplastics in form of PS beads. For example, when exposed to 0.1-μm PS beads, the lipid droplet count was 93% higher, the droplets were up to 56% larger, and the area of the nematode body covered by lipids was up to 79% higher than in unexposed nematodes. The measured values tended to increase as PS bead sizes decreased. Cultivating the nematodes for 96 h under restricted food conditions in the absence of beads reproduced the altered lipid storage and suggested that it was triggered by food deprivation, including that induced by the dilutional effects of PS bead exposure. Our study demonstrates the utility of CARS microscopy to comprehensively image the smaller microplastics (<10 μm) ingested by nematodes and possibly other biota in investigations of the effects at the level of the individual organism.
显示更多 [+] 显示较少 [-]Biological, histological and immunohistochemical studies on the toxicity of spent coffee grounds and caffeine on the larvae of Aedes aegypti (Diptera: Culicidae) 全文
2021
Miranda, Franciane Rosa | Fernandes, Kenner Morais | Bernardes, Rodrigo Cupertino | Martins, Gustavo Ferreira
The mosquito Aedes aegypti is a primary vector for major arboviruses, and its control is mainly based on the use of insecticides. Caffeine and spent coffee grounds (CG) are potential agents in controlling Ae. aegypti by reducing survival and blocking larval development. In this study, we analyzed the effects of treatment with common CG (CCG: with caffeine), decaffeinated CG (DCG: with low caffeine), and pure caffeine on the survival, behavior, and morphology of the midgut of Ae. aegypti under laboratory conditions. Third instar larvae (L3) were exposed to different concentrations of CCG, DCG, and caffeine. All compounds significantly affected larval survival, and sublethal concentrations reduced larval locomotor activity, delayed development, and reduced adult life span. Damage to the midgut of treated larvae included changes in epithelial morphology, increased number of peroxidase-positive cells (more abundant in DCG-treated larvae), and caspase 3-positive cells (more abundant in CCG-treated larvae), suggesting that the treatments triggered cell damage, leading to activation of cell death. In addition, the treatments reduced the FMRFamide-positive enteroendocrine cells and dividing cells compared to the control. CG and caffeine have larvicidal effects on Ae. aegypti that warrant field testing for their potential to control mosquitoes.
显示更多 [+] 显示较少 [-]Arsenic speciation in rice bran: Agronomic practices, postharvest fermentation, and human health risk assessment across the lifespan 全文
2021
Weber, Annika M. | Baxter, Bridget A. | McClung, Anna | Lamb, Molly M. | Becker-Dreps, Sylvia | Vilchez, Samuel | Koita, Ousmane | Wieringa, Frank | Ryan, Elizabeth P.
Arsenic (As) exposure is a global public health concern affecting millions worldwide and stems from drinking water and foods containing As. Here, we assessed how agronomic practices and postharvest fermentation techniques influence As concentrations in rice bran, and calculated health risks from consumption. A global suite of 53 rice brans were tested for total As and speciation. Targeted quantification of inorganic As (iAs) concentrations in rice bran were used to calculate Target Hazard Quotient (THQ) and Lifetime Cancer Risk (LCR) across the lifespan. Mean iAs was highest in Thailand rice bran samples (0.619 mg kg⁻¹) and lowest in Guatemala (0.017 mg kg⁻¹) rice bran samples. When comparing monosodium-methanearsonate (MSMA) treated and the Native-soil counterpart under the irrigation technique Alternate Wetting and Drying (AWD) management, the MSMA treatment had significantly higher total As (p = 0.022), and iAs (p = 0.016). No significant differences in As concentrations were found between conventional and organic production, nor between fermented and non-fermented rice bran. Health risk assessment calculations for the highest iAs-rice bran dosage scenario for adults, children and infants exceeded THQ and LCR thresholds, and LCR was above threshold for median iAs-rice bran. This environmental exposure investigation into rice bran provides novel information with food safety guidance for an emerging global ingredient.
显示更多 [+] 显示较少 [-]Neonicotinoids from coated seeds toxic for honeydew-feeding biological control agents 全文
2021
Calvo-Agudo, Miguel | Dregni, Jonathan | González-Cabrera, Joel | Dicke, Marcel | Heimpel, George E. | Tena, Alejandro
Neonicotinoids from coated seeds toxic for honeydew-feeding biological control agents 全文
2021
Calvo-Agudo, Miguel | Dregni, Jonathan | González-Cabrera, Joel | Dicke, Marcel | Heimpel, George E. | Tena, Alejandro
Seed coating (‘seed treatment’) is the leading delivery method of neonicotinoid insecticides in major crops such as soybean, wheat, cotton and maize. However, this prophylactic use of neonicotinoids is widely discussed from the standpoint of environmental costs. Growing soybean plants from neonicotinoid-coated seeds in field, we demonstrate that soybean aphids (Aphis glycines) survived the treatment, and excreted honeydew containing neonicotinoids. Biochemical analyses demonstrated that honeydew excreted by the soybean aphid contained substantial concentrations of neonicotinoids even one month after sowing of the crop. Consuming this honeydew reduced the longevity of two biological control agents of the soybean aphid, the predatory midge Aphidoletes aphidimyza and the parasitic wasp Aphelinus certus. These results have important environmental and economic implications because honeydew is the main carbohydrate source for many beneficial insects in agricultural landscapes.
显示更多 [+] 显示较少 [-]Neonicotinoids from coated seeds toxic for honeydew-feeding biological control agents 全文
2021
Calvo-Agudo, Miguel | Dregni, Jonathan | González-Cabrera, Joel | Dicke, Marcel | Heimpel, George E. | Tena, Alejandro
Seed coating (‘seed treatment’) is the leading delivery method of neonicotinoid insecticides in major crops such as soybean, wheat, cotton and maize. However, this prophylactic use of neonicotinoids is widely discussed from the standpoint of environmental costs. Growing soybean plants from neonicotinoid-coated seeds in field, we demonstrate that soybean aphids (Aphis glycines) survived the treatment, and excreted honeydew containing neonicotinoids. Biochemical analyses demonstrated that honeydew excreted by the soybean aphid contained substantial concentrations of neonicotinoids even one month after sowing of the crop. Consuming this honeydew reduced the longevity of two biological control agents of the soybean aphid, the predatory midge Aphidoletes aphidimyza and the parasitic wasp Aphelinus certus. These results have important environmental and economic implications because honeydew is the main carbohydrate source for many beneficial insects in agricultural landscapes.
显示更多 [+] 显示较少 [-]Neonicotinoids from coated seeds toxic for honeydew-feeding biological control agents 全文
2021
Calvo-Agudo, Miguel | Dregni, Jonathan | González-Cabrera, Joel | Dicke, Marcel | Heimpel, George E. | Tena, Alejandro
Seed coating (‘seed treatment’) is the leading delivery method of neonicotinoid insecticides in major crops such as soybean, wheat, cotton and maize. However, this prophylactic use of neonicotinoids is widely discussed from the standpoint of environmental costs. Growing soybean plants from neonicotinoid-coated seeds in field, we demonstrate that soybean aphids (Aphis glycines) survived the treatment, and excreted honeydew containing neonicotinoids. Biochemical analyses demonstrated that honeydew excreted by the soybean aphid contained substantial concentrations of neonicotinoids even one month after sowing of the crop. Consuming this honeydew reduced the longevity of two biological control agents of the soybean aphid, the predatory midge Aphidoletes aphidimyza and the parasitic wasp Aphelinus certus. These results have important environmental and economic implications because honeydew is the main carbohydrate source for many beneficial insects in agricultural landscapes.
显示更多 [+] 显示较少 [-]Three-dimensional model of magnetic susceptibility in forest topsoil: An indirect method to discriminate contaminant migration 全文
2021
Łukasik, Adam | Szuszkiewicz, Marcin | Wanic, Tomasz | Gruba, Piotr
Three-dimensional model of magnetic susceptibility in forest topsoil: An indirect method to discriminate contaminant migration 全文
2021
Łukasik, Adam | Szuszkiewicz, Marcin | Wanic, Tomasz | Gruba, Piotr
Soil magnetic susceptibility (MS) is an important parameter in pollution studies owing to its relationship with atmospheric deposition, and the concomitance of technogenic magnetic particles (TMPs) with potentially toxic elements (PTEs), Fe and Mn. In this study, we performed a detailed soil study under tree canopies for a forest area with high historical TMP-bearing industrial dust deposition. The technogenic sources of magnetic signals in topsoil were analyzed via scanning electron microscope electron dispersive spectroscopy (SEM/EDS), while the minor role of geogenic sources was obtained from soil profile analysis. To our knowledge, this is the first study to show soil TMP distribution in three dimensional (3D) space. In addition, using the data from 275 soil cores and 8250 individual measurements, 3D maps of MS for four tree species were plotted. There is a noticeable difference between coniferous (spruce and pine) and deciduous (beech and oak) species regarding depth of maximum concentration of magnetic particles in the topsoil. For beech and oak, maximum MS values were measured at 3 cm depth; pine and spruce, maximum MS values were measured at 5 cm depth. However, no significant differences were found among tree species in terms of mean MS or PTE contents. This suggests that there is little different among tree species in terms of dust capture over their life span. Significant correlations between MS and other parameters (PTEs and organic matter contents) present new possibilities for spatial 3D analysis of topsoil horizons.
显示更多 [+] 显示较少 [-]Three-dimensional model of magnetic susceptibility in forest topsoil: An indirect method to discriminate contaminant migration 全文
Adam Łukasik | Marcin Szuszkiewicz | Tomasz Wanic | Piotr Gruba
Soil magnetic susceptibility (MS) is an important parameter in pollution studies owing to its relationship with atmospheric deposition, and the concomitance of technogenic magnetic particles (TMPs) with potentially toxic elements (PTEs), Fe and Mn. In this study, we performed a detailed soil study under tree canopies for a forest area with high historical TMP-bearing industrial dust deposition. The technogenic sources of magnetic signals in topsoil were analyzed via scanning electron microscope electron dispersive spectroscopy (SEM/EDS), while the minor role of geogenic sources was obtained from soil profile analysis. To our knowledge, this is the first study to show soil TMP distribution in three dimensional (3D) space. In addition, using the data from 275 soil cores and 8250 individual measurements, 3D maps of MS for four tree species were plotted. There is a noticeable difference between coniferous (spruce and pine) and deciduous (beech and oak) species regarding depth of maximum concentration of magnetic particles in the topsoil. For beech and oak, maximum MS values were measured at 3 cm depth; pine and spruce, maximum MS values were measured at 5 cm depth. However, no significant differences were found among tree species in terms of mean MS or PTE contents. This suggests that there is little different among tree species in terms of dust capture over their life span. Significant correlations between MS and other parameters (PTEs and organic matter contents) present new possibilities for spatial 3D analysis of topsoil horizons. | 3D analysis, Magnetic susceptibility, Tree crowns, Forest soil, Contaminants migration | 100 | 1-11 | 273
显示更多 [+] 显示较少 [-]Assessment on chronic and transgenerational toxicity of methamphetamine to Caenorhabditis elegans and associated aquatic risk through toxicity indicator sensitivity distribution (TISD) analysis 全文
2021
Wang, Zhenglu | Dai, Shuiping | Wang, Jinze | Du, Wei | Zhu, Lin
Evidence about the adverse effects of methamphetamine (METH) on invertebrates is scarce. Hence, C. elegans, a representative invertebrate model, was exposed to METH at environmental levels to estimate chronic and transgenerational toxicity. The results of chronic exposure were integrated into an underlying toxicity framework of METH in invertebrates (e.g., benthos) at environmentally relevant concentrations. The induction of cellular oxidative damage-induced apoptosis and fluctuation of ecologically important traits (i.e., feeding and locomotion) might be attributed by the activation of the longevity regulating pathway regulated by DAF-16/FOXO, and detoxification by CYP family enzymes. The adverse effects to the organism level included impaired viability and decreased fecundity. The results from transgenerational exposure elucidated the cumulative METH-induced damage in invertebrates. Finally, a new risk assessment method named toxicity indicator sensitivity distribution (TISD) analysis was proposed by combining multiple toxicity indicator test data (ECₓ) to derive the hazardous concentration for 10% indicators (C₁₀) of one species. The risk quotient (RQ) values calculated by measured environmental concentrations and C₁₀ in southern China, southeastern Australia, and the western US crossed the alarm line (RQ = 5), suggesting a need for long-term monitoring.
显示更多 [+] 显示较少 [-]Developmental exposures to perfluorooctanesulfonic acid (PFOS) impact embryonic nutrition, pancreatic morphology, and adiposity in the zebrafish, Danio rerio 全文
2021
Sant, Karilyn E. | Annunziato, Kate | Conlin, Sarah | Teicher, Gregory | Chen, Phoebe | Venezia, Olivia | Downes, Gerald B. | Park, Yeonhwa | Timme-Laragy, Alicia R.
Perfluorooctanesulfonic acid (PFOS) is a persistent environmental contaminant previously found in consumer surfactants and industrial fire-fighting foams. PFOS has been widely implicated in metabolic dysfunction across the lifespan, including diabetes and obesity. However, the contributions of the embryonic environment to metabolic disease remain uncharacterized. This study seeks to identify perturbations in embryonic metabolism, pancreas development, and adiposity due to developmental and subchronic PFOS exposures and their persistence into later larval and juvenile periods. Zebrafish embryos were exposed to 16 or 32 μM PFOS developmentally (1–5 days post fertilization; dpf) or subchronically (1–15 dpf). Embryonic fatty acid and macronutrient concentrations and expression of peroxisome proliferator-activated receptor (PPAR) isoforms were quantified in embryos. Pancreatic islet morphometry was assessed at 15 and 30 dpf, and adiposity and fish behavior were assessed at 15 dpf. Concentrations of lauric (C12:0) and myristic (C14:0) saturated fatty acids were increased by PFOS at 4 dpf, and PPAR gene expression was reduced. Incidence of aberrant islet morphologies, principal islet areas, and adiposity were increased in 15 dpf larvae and 30 dpf juvenile fish. Together, these data suggest that the embryonic period is a susceptible window of metabolic programming in response to PFOS exposures, and that these early exposures alone can have persisting effects later in the lifecourse.
显示更多 [+] 显示较少 [-]Sublethal effects of DBE-DBCH diastereomers on physiology, behavior, and gene expression of Daphnia magna 全文
2021
Seyoum, Asmerom | Kharlyngdoh, Joubert Banjop | Paylar, Berkay | Olsson, Per-Erik
1,2-dibromo-4-(1,2-dibromoethyl)-cyclohexane (DBE-DBCH) is a brominated flame retardant used in commercial and industrial applications. The use of DBE-DBCH containing products has resulted in an increased release into the environment. However, limited information is available on the long-term effects of DBE-DBCH and its effects in aquatic invertebrates. Thus, the present study was aimed at determining how DBE-DBCH diastereomers (αβ and γδ) affects aquatic invertebrates using Daphnia magna as a model organism. Survival, reproduction, feeding, swimming behavior and toxicogenomic responses to environmental relevant concentrations of DBE-DBCH were analyzed. Chronic exposure to DBE-DBCH resulted in decreased lifespan, and reduced fecundity. Expression of genes involved in reproductive processes, vtg1 and jhe, were also inhibited. DBE-DBCH also induced hypoxia by inhibiting the transcription of genes involved in heme biosynthesis and oxygen transport. Furthermore, DBE-DBCH also inhibited feeding resulting in emptiness of the alimentary canal. Increased expression of the stress response biomarkers was observed following DBE-DBCH exposure. In addition, DBE-DBCH diastereomers also altered the swimming behavior of Daphnia magna. The present study demonstrates that DBE-DBCH cause multiple deleterious effects on Daphnia magna, including effects on reproduction and hormonal systems. These endocrine disrupting effects are in agreement with effects observed on vertebrates. Furthermore, as is the case in vertebrates, DBE-DBCH γδ exerted stronger effects than DBE-DBCH αβ on Daphnia magna. This indicate that DBE-DBCH γδ has properties making it more toxic to all so far studied animals than DBE-DBCH αβ.
显示更多 [+] 显示较少 [-]Life stage-dependent toxicities of 1-ethyl-3-methylimidazolium bromide on Caenorhabditis elegans 全文
2020
Liu, Hong | Mo, Lingyun | Hou, Meifang | Zhang, Jing
Ionic liquids (ILs) are considered as extracting solvents in soil remediation. However, they can be pollutants themselves, and their own toxicities are of concerns. Notably, organisms were exposed to pollutants at random life stages in actual environmental exposure scenario, which is different from the set-up of one uniform life stage in usual experiment designs. The influence of life stages on ILs toxicities will provide essential information on their actual environmental risks. In the present study, effects of 1-ethyl-3-methylimidazolium bromide ([C₂mim]Br) were measured on C. elegans with egg exposure and adult exposure. In egg exposure, [C₂mim]Br increased the lifespan, stimulated initial reproduction and inhibited the total reproduction. Biochemical indices including oxidative stress, antioxidant responses and oxidative damage were further measured to explore the toxicity mechanisms. Results showed that [C₂mim]Br significantly stimulated O₂⁻· as the oxidative stress and superoxide dismutase (SOD) as the antioxidant defense. In adult exposure, [C₂mim]Br inhibited initial reproduction, total reproduction and lifespan. Biochemical results showed that [C₂mim]Br significantly stimulated H₂O₂ and oxidized glutathione (GSSG). The overall findings demonstrated that [C₂mim]Br caused life stage-dependent toxicities on C. elegans. Future studies are still needed for the detailed mechanisms.
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